University Medical Center Utrecht Brain Center (the UMC Utrecht is part of the ERN EpiCARE), Utrecht University, the Netherlands.
Eur J Paediatr Neurol. 2020 Jan;24:40-42. doi: 10.1016/j.ejpn.2019.12.014. Epub 2019 Dec 20.
Epilepsy surgery is the most effective treatment option for children with refractory focal lesional epilepsy, with seizure-freedom rates exceeding 70% two years after surgery. Although numbers of procedures in children are increasing over time, epilepsy surgery remains underutilized. Particularly in young children with developmental delay, arrest, or even regression, surgery can improve cognitive outcome. Many factors determine eventual developmental abilities, of which epilepsy duration is the most important modifiable predictor. Earlier surgery is not only associated with higher seizure-freedom rates, it also improves postoperative developmental outcomes. Every child with focal lesional epilepsy should therefore be referred early, to evaluate the possibilities of epilepsy surgery.
癫痫手术是治疗耐药性局灶性病变性癫痫儿童的最有效治疗选择，手术后两年内的无癫痫发作率超过 70%。尽管随着时间的推移，儿童手术数量有所增加，但癫痫手术的应用仍不足。特别是对于发育迟缓、发育停滞甚至倒退的幼儿，手术可以改善认知结果。许多因素决定了最终的发育能力，其中癫痫持续时间是最重要的可改变预测因素。早期手术不仅与更高的无癫痫发作率相关，还能改善术后发育结果。因此，每一位患有局灶性病变性癫痫的儿童都应尽早接受转介，以评估癫痫手术的可能性。
