又一起劫持！一些肠道病毒为了自身利益而劫持 c10orf76/PI4KB 复合物。
Another hijack! Some enteroviruses co-opt the c10orf76/PI4KB complex for their own good.
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Illkirch, France.
出版信息
EMBO Rep. 2020 Feb 5;21(2):e49876. doi: 10.15252/embr.201949876. Epub 2020 Jan 9.
Abstract
Enteroviruses, members of the Picornaviridae family, are non-enveloped and single-stranded RNA viruses responsible for several human diseases. During infection, these viruses build membrane-bound organelles, called replication organelles (ROs), where new virions are assembled. ROs are highly enriched in phosphatidylinositol 4-phosphate (PI4P) produced by the host lipid kinase PI4KB. In this issue of EMBO Reports, McPhail et al [1] characterize a complex, formed by PI4KB and the c10orf76 protein, which is involved in PI4P production. They show that this machinery is hijacked by specific enteroviruses such as coxsackievirus A10 for their replication.
摘要
肠道病毒属于小 RNA 病毒科，是无包膜的单链 RNA 病毒，可引发多种人类疾病。在感染过程中，这些病毒会构建膜结合细胞器，称为复制细胞器 (RO)，新的病毒粒子在其中组装。RO 中高度富集了宿主脂质激酶 PI4KB 产生的磷脂酰肌醇 4-磷酸 (PI4P)。在本期的《EMBO 报告》中，McPhail 等人 [1] 描述了一个由 PI4KB 和 c10orf76 蛋白组成的复合物，该复合物参与 PI4P 的产生。他们表明，这种机制被特定的肠道病毒（如柯萨奇病毒 A10）劫持，用于其复制。
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