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内源性抗原负载纳米颗粒对抗原呈递细胞的靶向和特异性激活可引发肿瘤特异性免疫。

Targeting and Specific Activation of Antigen-Presenting Cells by Endogenous Antigen-Loaded Nanoparticles Elicits Tumor-Specific Immunity.

作者信息

Chang Hao-Cai, Zou Zheng-Zhi, Wang Qiu-Hong, Li Jie, Jin Huan, Yin Qian-Xia, Xing Da

机构信息

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science South China Normal University Guangzhou 510631 China.

College of Biophotonics South China Normal University Guangzhou 510631 China.

出版信息

Adv Sci (Weinh). 2019 Nov 8;7(1):1900069. doi: 10.1002/advs.201900069. eCollection 2020 Jan.

DOI:10.1002/advs.201900069
PMID:31921548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6947714/
Abstract

Immunotherapy has shown tremendous promise for improving cancer treatment. Unfortunately, antigen-presenting cells (APCs) in cancer patients cannot effectively recognize and process tumor antigens to activate host immune responses. In this study, an approach is developed to improve cancer immunotherapy that utilizes endogenous antigen-carrying nanoparticles (EAC-NPs), which encompasses a set of antigens isolated from solid tumors and adjuvants. The EAC-NPs specifically target APCs and subsequently result in enhanced T cell responses and improved antitumor efficacy. Mechanistic studies reveal that the EAC-NPs enhance and prolong the presence of immune compounds in APCs, which ensure persistent antigen loading and stimulation, induce a rapid proliferation of CD4 and CD8 T cells, and significantly increase the ratios of intratumoral CD4 T/T and CD8 T/T. The work using nanotechnology provides a promising strategy in improving antitumor immunity by enhancing the immunogenicity and presentation of tumor self-antigens for cancer immunotherapy.

摘要

免疫疗法在改善癌症治疗方面已展现出巨大潜力。不幸的是，癌症患者体内的抗原呈递细胞（APC）无法有效识别和处理肿瘤抗原以激活宿主免疫反应。在本研究中，开发了一种利用内源性携带抗原的纳米颗粒（EAC-NP）来改善癌症免疫疗法的方法，该纳米颗粒包含一组从实体瘤中分离出的抗原和佐剂。EAC-NP特异性靶向APC，随后导致T细胞反应增强和抗肿瘤疗效提高。机制研究表明，EAC-NP增强并延长了免疫化合物在APC中的存在，确保持续的抗原负载和刺激，诱导CD4和CD8 T细胞快速增殖，并显著提高肿瘤内CD4 T/T和CD8 T/T的比例。这项利用纳米技术的工作通过增强肿瘤自身抗原的免疫原性和呈递，为癌症免疫疗法改善抗肿瘤免疫提供了一种有前景的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/5c070a0c466b/ADVS-7-1900069-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/7d67983d0b4c/ADVS-7-1900069-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/f738759d821a/ADVS-7-1900069-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/d27f4a09c1a9/ADVS-7-1900069-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/e239870bf2c3/ADVS-7-1900069-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/e3cec07bc941/ADVS-7-1900069-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/59d31cab9aae/ADVS-7-1900069-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/f30e359a58cc/ADVS-7-1900069-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/5c070a0c466b/ADVS-7-1900069-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/7d67983d0b4c/ADVS-7-1900069-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/f738759d821a/ADVS-7-1900069-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/d27f4a09c1a9/ADVS-7-1900069-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/e239870bf2c3/ADVS-7-1900069-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/e3cec07bc941/ADVS-7-1900069-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/59d31cab9aae/ADVS-7-1900069-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/f30e359a58cc/ADVS-7-1900069-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d4/6947714/5c070a0c466b/ADVS-7-1900069-g008.jpg

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