波斯医学中湿拔罐疗法与干拔罐疗法之间Th1/Th2和Treg/Th17比率的比较。
Comparison of Th1/Th2 and Treg/Th17 ratios between wet and dry cupping therapies in Persian medicine.
作者信息
Soleimani Reza, Mohammadi Mojgan, Saghebi Seyed Ahmad, Taghipour Ali, Khorsand Vakilzadeh Ali, Tavakkol Afshari Jalil
机构信息
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Avicenna J Phytomed. 2020 Jan-Feb;10(1):24-34.
OBJECTIVE
In Persian medicine (PM), wet-cupping therapy (WCT) is the most utilized approach. WCT is mostly done between the shoulders, which is referred to as "" in the Persian language. CD4+T cells also refer to T helper lymphocytes play a critical role in the immune system. Naïve CD4+ T cells differentiate into at least four subsets, T helper 1 (Th1), T helper 2 (Th2), T helper 17 (Th17), and T regulatory (Treg) cells. The master regulator controlling each subset have been defined as follows, (Th1), (Th2), (Th17), (Treg). The purpose of this study was to compare the effect of WCT and dry-cupping therapy (DCT) on the ratios of Th1/Th2 and Treg /Th17 in healthy individuals.
MATERIALS AND METHODS
Participants were divided randomly into two groups of 41 men in the WCT group and 40 men in the DCT group. Blood was taken, before, one and four weeks after the intervention. RNA was extracted from the peripheral blood mononuclear cells and the expression of , , , and genes were determined by using SYBR green RT-PCR technique.
RESULTS
The results showed that WCT increased the expression of, , and transcription factor genes (p=0.009, p=0.001, and p=0.021, respectively). Although in the WCT group, the ratio of / increased (p=0.048), but the ratio of / (Th1/Th2) decreased (p=0.971).
CONCLUSION
Our findings indicated that WCT may regulate the T subsets of lymphocyte and reduce inflammation.
目的
在波斯医学中，湿拔罐疗法是最常用的方法。湿拔罐疗法大多在肩部之间进行，在波斯语中称为“”。CD4 + T细胞也指T辅助淋巴细胞，在免疫系统中起关键作用。初始CD4 + T细胞至少分化为四个亚群，即辅助性T细胞1（Th1）、辅助性T细胞2（Th2）、辅助性T细胞17（Th17）和调节性T（Treg）细胞。控制每个亚群的主要调节因子定义如下：（Th1）、（Th2）、（Th17）、（Treg）。本研究的目的是比较湿拔罐疗法和干拔罐疗法对健康个体中Th1/Th2和Treg /Th17比例的影响。
材料与方法
参与者被随机分为两组，湿拔罐疗法组有41名男性，干拔罐疗法组有40名男性。在干预前、干预后1周和4周采集血液。从外周血单核细胞中提取RNA，并使用SYBR green RT-PCR技术测定、、和基因的表达。
结果
结果表明，湿拔罐疗法增加了、和转录因子基因的表达（分别为p = 0.009、p = 0.001和p = 0.021）。虽然在湿拔罐疗法组中，/的比例增加（p = 0.048），但/（Th1/Th2）的比例下降（p = 0.971）。
结论
我们的研究结果表明，湿拔罐疗法可能调节淋巴细胞的T亚群并减轻炎症。
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