神经控制与口渴、钠欲和饥饿的调节。
Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger.
机构信息
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; Department of Neuroscience, The Scripps Research Institute, La Jolla, California, USA.
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.
出版信息
Cell. 2020 Jan 9;180(1):25-32. doi: 10.1016/j.cell.2019.11.040.
Abstract
The function of central appetite neurons is instructing animals to ingest specific nutrient factors that the body needs. Emerging evidence suggests that individual appetite circuits for major nutrients-water, sodium, and food-operate on unique driving and quenching mechanisms. This review focuses on two aspects of appetite regulation. First, we describe the temporal relationship between appetite neuron activity and consumption behaviors. Second, we summarize ingestion-related satiation signals that differentially quench individual appetite circuits. We further discuss how distinct appetite and satiation systems for each factor may contribute to nutrient homeostasis from the functional and evolutional perspectives.
摘要
中枢食欲神经元的功能是指示动物摄入身体所需的特定营养因子。新出现的证据表明，主要营养物质（水、钠和食物）的个体食欲回路基于独特的驱动和抑制机制。本综述重点关注食欲调节的两个方面。首先，我们描述了食欲神经元活动与摄食行为之间的时间关系。其次，我们总结了与摄食相关的饱食信号，这些信号可差异化地抑制个体食欲回路。我们进一步讨论了从功能和进化角度来看，每种因子的不同食欲和饱食系统如何有助于营养稳态。
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本文引用的文献
1
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Cell. 2019 Nov 14;179(5):1129-1143.e23. doi: 10.1016/j.cell.2019.10.031.
2
The Lateral Hypothalamic and BNST GABAergic Projections to the Anterior Ventrolateral Periaqueductal Gray Regulate Feeding.外侧下丘脑和 BNST 的 GABA 能投射到前腹外侧导水管周围灰质调节摄食。
Cell Rep. 2019 Jul 16;28(3):616-624.e5. doi: 10.1016/j.celrep.2019.06.051.
3
Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits.自然奖赏和药物奖赏通过不同的途径汇聚到协调的下丘脑和奖赏回路。
Neuron. 2019 Sep 4;103(5):891-908.e6. doi: 10.1016/j.neuron.2019.05.050. Epub 2019 Jul 2.
4
Temporally and Spatially Distinct Thirst Satiation Signals.时间和空间上不同的口渴饱足信号。
Neuron. 2019 Jul 17;103(2):242-249.e4. doi: 10.1016/j.neuron.2019.04.039. Epub 2019 May 29.
5
Sustained NPY signaling enables AgRP neurons to drive feeding.持续的 NPY 信号使 AgRP 神经元能够驱动摄食。
Elife. 2019 Apr 29;8:e46348. doi: 10.7554/eLife.46348.
6
A gut-to-brain signal of fluid osmolarity controls thirst satiation.液体渗透压的肠-脑信号控制口渴感的满足。
Nature. 2019 Apr;568(7750):98-102. doi: 10.1038/s41586-019-1066-x. Epub 2019 Mar 27.
7
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Cell Metab. 2019 Mar 5;29(3):681-694.e5. doi: 10.1016/j.cmet.2018.10.016. Epub 2018 Nov 21.
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