Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110433. doi: 10.1016/j.msec.2019.110433. Epub 2019 Nov 16.
To instill pure Ti with an antibacterial effect, Cu was added by metallurgical alloying to produce Ti-5 wt% Cu alloy (Ti-5Cu alloy). The precipitation of the likes of TiCu in a Ti-Cu alloy is one of the factors that influences its antibacterial property. However, in the present study, Ti-5Cu alloy precipitates with different microstructures were obtained by applying heat treatment at different temperatures and for different durations. After the heat treatment, metallographic, microstructure, and element analyses were performed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) combined with energy dispersive X-ray spectroscopy (EDS). The antibacterial property of the Ti-5Cu alloy was assessed by the plated-count method using Escherichia coli (E. coli). The microstructure analysis revealed that the solution-treated alloy had no precipitation, while the aged alloy contained precipitations of intermetallic TiCu compound. The aged alloy exhibited better antibacterial performance as the duration of the aging treatment increased. The optimal heat treatment for Ti-5Cu was found to be aging at 700 °C for 4 h, at which point the nucleation formation of the TiCu particles would assume an acicular morphology. These acicular precipitates exhibit a high Cu content which, in turn, influences the antibacterial performance.
为了赋予纯钛抗菌效果，通过冶金合金化添加 Cu 来生产 Ti-5wt%Cu 合金（Ti-5Cu 合金）。Ti-Cu 合金中 TiCu 等的析出是影响其抗菌性能的因素之一。然而，在本研究中，通过在不同温度和不同时间下进行热处理，获得了具有不同微观结构的 Ti-5Cu 合金析出物。热处理后，使用扫描电子显微镜（SEM）和透射电子显微镜（TEM）结合能谱分析（EDS）进行金相、微观结构和元素分析。通过使用大肠杆菌（E. coli）的镀片计数法评估 Ti-5Cu 合金的抗菌性能。微观结构分析表明，固溶处理后的合金没有析出物，而时效处理后的合金含有金属间化合物 TiCu 的析出物。随着时效处理时间的增加，时效处理后的合金表现出更好的抗菌性能。Ti-5Cu 的最佳热处理被发现是在 700°C 时效 4 小时，此时 TiCu 颗粒的形核形成呈针状形态。这些针状沉淀物具有较高的 Cu 含量，从而影响抗菌性能。
