Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China.
Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China; Research Center for Metallic Wires, Northeastern University, Shenyang 110819, China.
Mater Sci Eng C Mater Biol Appl. 2021 Jul;126:112116. doi: 10.1016/j.msec.2021.112116. Epub 2021 Apr 20.
In order to prepare a titanium with a low elastic modulus and good antibacterial property to meet the requirements as a biomedical material, Ti-13Nb-13Zr-5Cu (TNZ-5Cu) alloy was prepared by high vacuum consume electric arc melting furnace and then subjected to a solution treatment at 950 °C followed by a short-term aging treatment at 600 °C, for 15 min, 30 min, 1 h and 2 h, respectively. The microstructure, mechanical property, antibacterial property and biocompatibility of TNZ-5Cu were investigated in detail. The research results have shown that the solid solution treated alloy was mainly composed of β-phase and α″-phase, while the aged alloys of β-phase, α″-phase, α-phase and TiCu. Compared with Ti-13Nb-13Zr alloy (65 GPa) and Ti-6Al-4 V alloy (111 GPa), the elastic modulus of TNZ-5Cu alloy after solution treatment was about 72 GPa and increased with the aging treatment up to 85 GPa, and the hardness was maintained at a higher level than that of Ti-13Nb-13Zr alloys (288 HV). The bacteria plate count results showed that the antibacterial ability of TNZ-5Cu alloy increased with the extension of the aging duration from <60% at 15-30 min to >90% at 1-2 h. Cell experiments showed that all TNZ-5Cu alloy had good cell compatibility. The low modulus and the antibacterial property could provide potential to avoid stress shield and device-related inflection in the clinical application.
为了制备一种具有低弹性模量和良好抗菌性能的钛合金，以满足生物医学材料的要求，采用高真空自耗电弧炉制备 Ti-13Nb-13Zr-5Cu（TNZ-5Cu）合金，然后在 950°C 下进行固溶处理，再在 600°C 下进行短期时效处理，分别为 15min、30min、1h 和 2h。详细研究了 TNZ-5Cu 的微观结构、力学性能、抗菌性能和生物相容性。研究结果表明，固溶处理后的合金主要由β相和α″-相组成，时效后的合金由β相、α″-相、α相和 TiCu 组成。与 Ti-13Nb-13Zr 合金（65GPa）和 Ti-6Al-4V 合金（111GPa）相比，经固溶处理后的 TNZ-5Cu 合金的弹性模量约为 72GPa，随时效处理的进行而增加，最高可达 85GPa，硬度保持在较高水平高于 Ti-13Nb-13Zr 合金（288HV）。细菌平板计数结果表明，TNZ-5Cu 合金的抗菌能力随时效时间的延长而增加，从 15-30min 的<60%增加到 1-2h 的>90%。细胞实验表明，所有 TNZ-5Cu 合金均具有良好的细胞相容性。低模量和抗菌性能可为避免临床应用中的应力屏蔽和器械相关感染提供潜在的可能。
