3D Additive Manufacturing, Forming Technology group, Singapore Institute of Manufacturing and Technology, 73 Nanyang Drive, Singapore 637662, Singapore.
Department of Mechanical Engineering, 9 Engineering drive 1, #07-08 Block EA, National University of Singapore, Singapore 117575, Singapore.
Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110478. doi: 10.1016/j.msec.2019.110478. Epub 2019 Nov 23.
A semi-degradable Ti + Mg composite with superior compression and cytotoxicity properties have been successfully fabricated using ink jet 3D printing followed by capillary mediated pressureless infiltration technique targeting orthopaedic implant applications. The composite exhibited low modulus (5.2 GPa) and high ultimate compressive strength (418 MPa) properties matching that of the human cortical bone. Ti + Mg composites with stronger 3D interconnected open-porous Ti networks are possible to be fabricated via 3D printing. Corrosion rate of samples measured through immersion testing using 0.9%NaCl solution at 37 °C indicate almost negligible corrosion rate for porous Ti (~1.14 μm/year) and <1 mm/year for Ti + Mg composites for 5 days of immersion, respectively. The composite significantly increased the SAOS-2 osteoblastic bone cell proliferation rate when compared to the 3D printed porous Ti samples and the increase is attributed to the exogenous Mg ions originating from the Ti + Mg samples. The cell viability results indicated absent to mild cytotoxicity. An attempt is made to discuss the key considerations for net-shape fabrication of Ti + Mg implants using ink jet 3D printing followed by infiltration approach.
采用喷墨 3D 打印结合毛细管介导无压渗透技术，成功制备出具有优异压缩性能和细胞毒性的半可降解 Ti+Mg 复合材料，用于骨科植入物。该复合材料表现出低模量（5.2GPa）和高极限抗压强度（418MPa），与人类皮质骨相匹配。通过 3D 打印，有可能制造出具有更强 3D 互联开放式多孔 Ti 网络的 Ti+Mg 复合材料。通过在 37°C 的 0.9%NaCl 溶液中进行浸泡测试来测量样品的腐蚀速率，多孔 Ti（~1.14μm/年）的腐蚀速率几乎可以忽略不计，Ti+Mg 复合材料在浸泡 5 天后的腐蚀速率<1mm/年。与 3D 打印多孔 Ti 样品相比，该复合材料显著提高了 SAOS-2 成骨细胞的增殖率，这归因于 Ti+Mg 样品中存在外源 Mg 离子。细胞活力结果表明不存在或轻度细胞毒性。尝试讨论使用喷墨 3D 打印结合渗透方法对 Ti+Mg 植入物进行净成型制造的关键考虑因素。
