Ramezan Ghorbani Nahid, Qorbani Mostafa, Djalalinia Shirin, Kazemzadeh Atoofi Mehrdad, Tajbakhsh Ramin, Mansourian Morteza, Gorabi Armita Mahdavi, Asayesh Hamid, Soleimani Ali, Noroozi Mehdi
Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran.
Non-Communicable Diseases Research Center, Alborz University of Medical Science, Karaj, Iran.
Int J Prev Med. 2019 Dec 10;10:216. doi: 10.4103/ijpvm.IJPVM_458_17. eCollection 2019.
Chronic hemodialysis is a lifesaving procedure for end-stage renal failure patients who may lead to the transmission of oncogenic viral infections discussed as a major cause of liver disease and a potential cause of substantial morbidity and mortality. In this regard, the hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common infections that studied recently. This study aimed to review systematically all available documents on the prevalence of hepatitis D virus (HED), hepatitis E virus (HEV), hepatitis G virus (HGV), human T-lymphotropic virus (HTLV), human immunodeficiency virus (HIV), and Kaposi's sarcoma-associated herpes virus (KSHV) in Iranian hemodialysis patients.
We conducted a comprehensive systematic review of literature on the prevalence and factors associated with HED, HEV, HGV, HTLV, HIV, and KSHV in Iranian hemodialysis patients. Using Medical Subject Headings (MeSH) terms, Emtree, and related equal Persian key words, irrespective of age, date, and language, the main domestic databanks of Barekat, Scientific Information Database (SID), Iran-doc, and also international databases of PubMed and NLM Gateway (for MEDLINE), Institute of Scientific Information (ISI), and SCOPUS searched. Interest outcome of infection prevalence was confirmed based on reported positive tests of blood samples. Since the studied factors are very numerous and there is even a high heterogeneity in each factor, so the meta-analysis was not performed.
Based on our search strategy through comprehensive searching, 509 studies were found. From them, 314 articles were from international data bases and others from Iranian data banks. After excluding duplicates and overlapping studies, 41 studies were included in the analysis; 11 studies were relevant to HIV, 10 studies assigned to HEV, and 7 studies belonged to HGV field. The HDV, HTLV1,2, and KSHV were the other research subject areas. The prevalence of HIV, HGV, and HTLV1,2 ranged from 0% to 1.5%, 0% to 24.19%, and 0.6% to 70.4%, respectively, in different provinces.
This is the comprehensive systematic review on oncogenic viral infections prevalence in the Iranian hemodialysis patients. Present findings emphasize on requirement to evidence-based practical intervention for better prevention and control of problem. The findings could be used as a scientific evidence for developing related policies and highlighting the future plan of complementary researches.
对于终末期肾衰竭患者而言，慢性血液透析是一种挽救生命的治疗手段，但这可能导致致癌病毒感染的传播，而致癌病毒感染被认为是肝脏疾病的主要病因以及大量发病和死亡的潜在原因。在这方面，乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）是最近研究最多的感染类型。本研究旨在系统回顾所有关于伊朗血液透析患者中丁型肝炎病毒（HDV）、戊型肝炎病毒（HEV）、庚型肝炎病毒（HGV）、人类嗜T淋巴细胞病毒（HTLV）、人类免疫缺陷病毒（HIV）和卡波西肉瘤相关疱疹病毒（KSHV）感染率的现有文献。
我们对有关伊朗血液透析患者中HDV、HEV、HGV、HTLV、HIV和KSHV感染率及相关因素的文献进行了全面系统的回顾。使用医学主题词（MeSH）、Emtree以及相关的波斯文同义词，无论年龄、日期和语言，检索了主要的国内数据库Barekat、科学信息数据库（SID）、Iran-doc，以及国际数据库PubMed和NLM Gateway（用于MEDLINE）、科学信息研究所（ISI）和SCOPUS。根据血液样本检测呈阳性的报告来确定感染率这一感兴趣的结果。由于研究的因素众多，且每个因素甚至存在高度异质性，因此未进行荟萃分析。
基于我们通过全面检索的搜索策略，共找到509项研究。其中，3,14篇文章来自国际数据库，其他来自伊朗数据库。在排除重复和重叠研究后，41项研究被纳入分析；11项研究与HIV相关，10项研究涉及HEV，7项研究属于HGV领域。HDV、HTLV1、2和KSHV是其他研究主题领域。在不同省份，HIV、HGV和HTLV1、2的感染率分别为0%至1.5%、0%至24.19%和0.6%至70.4%。
这是对伊朗血液透析患者致癌病毒感染率的全面系统回顾。目前的研究结果强调需要进行基于证据的实际干预，以更好地预防和控制该问题。这些研究结果可作为制定相关政策和突出未来补充研究计划的科学依据。
