James K, Bridger J, Anthony P P
Area Department of Pathology, Royal Devon, University of Exeter, U.K.
J Pathol. 1988 Sep;156(1):37-44. doi: 10.1002/path.1711560109.
Fourteen cases of a benign lesion of the breast, often referred to as 'lactating' adenoma, are described. They were all first noticed during pregnancy. The microscopic changes are similar to those seen in the normal pregnant breast but vary in degree and are out of phase with it. Any association with fibroadenoma or fibrocystic disease seems coincidental. 'Lactating' adenomas are also clearly distinguishable from tubular adenomas, which consist of masses of closely set tubules, like ductules of the normal resting breast, and are not related to pregnancy. Immunocytochemistry using antisera to breast and tumour associated antigens can demonstrate clear differences between 'lactating' adenoma, other breast lesions, and the normal pregnant breast. A plea is made for the designation of these lesions as 'breast tumour of pregnancy' as they do not arise in the lactating period.
本文描述了14例乳腺良性病变病例，这类病变常被称为“哺乳期”腺瘤。它们均首次发现于孕期。其微观变化与正常妊娠乳腺相似，但程度有所不同且与之不同步。与纤维腺瘤或纤维囊性疾病的任何关联似乎都是巧合。“哺乳期”腺瘤也明显有别于管状腺瘤，管状腺瘤由紧密排列的小管团块组成，类似正常静止期乳腺的小导管，且与妊娠无关。使用针对乳腺及肿瘤相关抗原的抗血清进行免疫细胞化学检测，可明确显示“哺乳期”腺瘤、其他乳腺病变以及正常妊娠乳腺之间的差异。鉴于这些病变并非在哺乳期出现，故建议将其命名为“妊娠乳腺肿瘤”。
