O'Hara M F, Page D L
Hum Pathol. 1985 Jul;16(7):707-12. doi: 10.1016/s0046-8177(85)80156-8.
The tubular adenomas, lactating adenomas, and ectopic lactation- or gestation-associated benign lesions of the breast diagnosed during a 22-year period are reported. Forty-two breast adenomas (in 28 patients) that demonstrated lactational changes are reviewed, with special attention to classification and clinical presentation. Five ectopic lactating adenomas--three axillary or in the chest wall and two vulvar, the latter occurring in the same patient--were identified in three patients. The lesions in the remaining cases were fibroadenomas with lactational changes (16 patients) and lactating or tubular adenomas (nine patients). Striking histologic and clinical similarities between the tubular and lactating adenomas and the lesions identified as lactational changes within a fibroadenoma were observed, with foci of tubular adenomatous change present within otherwise typical fibroadenomas. The overlapping morphologic spectrum and the strong association with pregnancy or lactational influences blur the distinction between these entities and suggest a common pathogenesis. The cytologic features of lactational lesions of the breast and ectopic breast pose special problems in diagnosis by fine needle aspiration.
报告了22年间诊断出的乳腺管状腺瘤、泌乳性腺瘤以及乳腺异位泌乳或妊娠相关良性病变。回顾了42例（28名患者）表现出泌乳改变的乳腺腺瘤，并特别关注其分类和临床表现。在3名患者中发现了5例异位泌乳性腺瘤，其中3例位于腋窝或胸壁，2例位于外阴，后者发生在同一患者身上。其余病例的病变为伴有泌乳改变的纤维腺瘤（16例患者）以及泌乳性腺瘤或管状腺瘤（9例患者）。观察到管状腺瘤和泌乳性腺瘤与纤维腺瘤内被确定为泌乳改变的病变之间存在显著的组织学和临床相似性，在典型的纤维腺瘤中存在管状腺瘤样改变灶。形态学谱的重叠以及与妊娠或泌乳影响的强烈关联模糊了这些实体之间的区别，并提示存在共同的发病机制。乳腺泌乳性病变和异位乳腺的细胞学特征给细针穿刺诊断带来了特殊问题。
