Kampouras Asterios, Hatziagorou Elpis, Avramidou Vasiliki, Georgopoulou Vasiliki, Kirvassilis Fotios, Tsanakas John
Pediatric Pulmonology and CF Unit, 3 Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Radiology Department, Hippokration Hospital, Thessaloniki, Greece.
Pulm Med. 2019 Dec 9;2019:3786245. doi: 10.1155/2019/3786245. eCollection 2019.
Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients.
To evaluate whether colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if colonization can predict exercise intolerance.
Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit.
78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO peak: 79.1%) were evaluated: 33 were chronically colonized with , 24 were intermittently colonized whereas 21 were free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO peak% ( < 0.001), LCI ( < 0.001), as well as FEV1% ( < 0.001) and FVC% ( < 0.001). colonization could predict VO peak% ( < 0.001, : -0.395).
Exercise capacity as reflected by peak oxygen uptake is reduced in colonized patients and reflects lung structural damages as shown on HRCT. colonization could predict exercise limitation among CF patients.
心肺运动试验（CPET）已被公认为评估囊性纤维化（CF）患者疾病负担和运动能力的一种有价值的方法。
评估定植状态是否会影响CF患者的运动能力、肺清除指数（LCI）和高分辨率计算机断层扫描（HRCT）指标；检查定植是否可预测运动不耐受。
78名CF儿童和成人（31名男性），平均（范围）年龄17.08（6.75；24.25），在入院或随访当天进行了肺活量测定、多次呼吸冲洗法（MBW）、CPET以及HRCT检查。
对78名CF患者（平均第1秒用力呼气容积（FEV1）：83.3%，平均LCI：10.9，平均峰值摄氧量（VO峰值）：79.1%）进行了评估：33人长期被[某种细菌]定植，24人间歇性被定植，而21人未被定植。三组之间在预测的峰值摄氧量百分比（VO峰值%，P<0.001）、LCI（P<0.001）以及FEV1%（P<0.001）和用力肺活量百分比（FVC%，P<0.001）方面观察到统计学显著差异。[某种细菌]定植可预测VO峰值%（P<0.001，r：-0.395）。
被[某种细菌]定植的患者中，由峰值摄氧量反映的运动能力降低，且如HRCT所示反映了肺部结构损伤。[某种细菌]定植可预测CF患者的运动受限。
