Jerome C P, Hendrickx A G
Department of Comparative Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC.
J Med Primatol. 1988;17(4):195-203.
Pregnant rhesus macaques were treated with 0.5 or 2.5 mg/kg triamcinolone acetonide (TAC) or 1.0 or 10.0 mg/kg dexamethasone sodium phosphate (DEX) between 20 and 50 gestational days (GD). Treatment with TAC at 2.5 mg/kg resulted in a fetal loss of 71%; 3/5 recovered fetuses displayed an encephalocele or meningocele. All other treatment groups displayed minor cranial skeletal abnormalities consistent with glucocorticoid-mediated teratogenesis. DEX was shown to have a lower teratogenic potential than TAC in this species.
在妊娠20至50天（GD）期间，给怀孕的恒河猴分别注射0.5或2.5毫克/千克的曲安奈德（TAC）或1.0或10.0毫克/千克的地塞米松磷酸钠（DEX）。以2.5毫克/千克的剂量注射TAC导致71%的胎儿死亡；5只存活胎儿中有3只出现脑膨出或脑膜膨出。所有其他治疗组均表现出与糖皮质激素介导的致畸作用一致的轻微颅骨骨骼异常。在该物种中，DEX的致畸潜力低于TAC。
