Parker R M, Hendrickx A G
J Craniofac Genet Dev Biol. 1982;2(3):219-31.
Triamcinolone-induced alteration of the notochordal-basichondrocranial relationship in the rhesus monkey. Timed-mated pregnant rhesus monkeys received triamcinolone acetonide (10 mg/kg, IM) during early organogenesis. Treated and control embryos and fetuses were removed by hysterotomy on days 35, 42, 50, 60, and 70. All treated cases 42 days or older exhibited craniofacial and brain defects. Microscopic examination showed abnormal notochordal folding and a shortened cranial base in the 35-day embryos prior to any observed CNS involvement. Bends, deviations, focal proliferation, and persistence of the notochord and altered cranial base were observed in older cases. This study supports the hypothesis that encephalocele and related CNS disorders could be secondary to a primary paraxial mesodermal insufficiency.
曲安奈德诱导的恒河猴脊索与颅底软骨关系改变。在器官发生早期，对定时交配的怀孕恒河猴给予曲安奈德（10mg/kg，肌肉注射）。在第35、42、50、60和70天通过子宫切开术取出经治疗和对照的胚胎及胎儿。所有42天及以上的治疗病例均表现出颅面和脑部缺陷。显微镜检查显示，在观察到任何中枢神经系统受累之前，35天的胚胎中脊索折叠异常且颅底缩短。在年龄较大的病例中观察到脊索弯曲、偏差、局灶性增殖和持续存在以及颅底改变。本研究支持脑膨出及相关中枢神经系统疾病可能继发于原发性轴旁中胚层功能不全这一假说。
