Safaei Maryam, Akhondpoor Manteghi Ali, Shahini Najmeh, Mohammadpour Amir Hooshang
Bojnord University of Medical Sciences, Bojnord, Iran.
Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Med J Islam Repub Iran. 2019 Oct 23;33:114. doi: 10.34171/mjiri.33.114. eCollection 2019.
Schizophrenia is associated with increased cardiovascular morbidity. Asymmetric dimethylarginine (ADMA) has been suggested as a cardiovascular biomarker. Treatment with atypical antipsychotics can increase some traditional risk factors of coronary artery disease. In addition to traditional risk factors, this study is carried out as a comparison of serum levels of ADMA and non-traditional factors among patients who take two types of atypical antipsychotics. In this clinical study, 57 schizophrenic patients with multiple episodes and 20 healthy voluntaries that fulfilled inclusion and exclusion criteria were entered into the study. The patients were divided into 3 groups (18 patients received risperidone alone, 20 patients received clozapine alone and 19 patients did not receive any drug). Plasma concentrations of ADMA, high-sensitivity Creactive protein (hs-CRP) and homocysteine were measured through enzyme-linked immunosorbent assay (ELISA), and traditional risk factors of metabolic syndrome were measured. Mean age of participants was 46.08±12.54 years. Moreover, the traditional (High-density lipoprotein (HDL), total cholesterol, waistline, and Body Mass Index (BMI)) and non-traditional factors (Homocysteine, hs-CRP) and ADMA were higher in patients with schizophrenia compared to healthy group (p≤ 0.05). Also, in the clozapine group, all mentioned non-traditional factors and ADMA were significantly higher than other groups (p≤ 0.05). In the clozapine group, levels of non-traditional factors and ADMA were significantly higher which indicates these patients are at risk of cardiovascular disease.
精神分裂症与心血管疾病发病率增加有关。非对称二甲基精氨酸（ADMA）被认为是一种心血管生物标志物。非典型抗精神病药物治疗可增加一些冠状动脉疾病的传统危险因素。除传统危险因素外，本研究旨在比较服用两种非典型抗精神病药物的患者血清ADMA水平和非传统因素。在这项临床研究中，57例有多次发作史的精神分裂症患者和20名符合纳入和排除标准的健康志愿者进入研究。患者分为3组（18例单独接受利培酮治疗，20例单独接受氯氮平治疗，19例未接受任何药物治疗）。通过酶联免疫吸附测定（ELISA）测量ADMA、高敏C反应蛋白（hs-CRP）和同型半胱氨酸的血浆浓度，并测量代谢综合征的传统危险因素。参与者的平均年龄为46.08±12.54岁。此外，与健康组相比，精神分裂症患者的传统因素（高密度脂蛋白（HDL）、总胆固醇、腰围和体重指数（BMI））、非传统因素（同型半胱氨酸、hs-CRP）和ADMA更高（p≤0.05）。此外，在氯氮平组中，所有上述非传统因素和ADMA均显著高于其他组（p≤0.05）。在氯氮平组中，非传统因素和ADMA水平显著更高，这表明这些患者有心血管疾病风险。
