Malhotra Nidhi, Kulhara Parmanand, Chakrabarti Subho, Grover Sandeep
Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Indian J Med Res. 2016 Apr;143(4):434-42. doi: 10.4103/0971-5916.184284.
BACKGROUND & OBJECTIVES: Though studies have reported high prevalence rates of metabolic syndrome among patients with bipolar disorder (BPAD) and schizophrenia, there is lack of data on the impact of the same on the patients' life. This study was aimed to assess the lifestyle related factors associated with metabolic syndrome (MetS) and to study the impact of MetS on functioning and quality of life (QOL) in patients with BPAD and schizophrenia.
A total of 102 patients with BPAD and 72 patients with schizophrenia attending the output unit of a tertiary care hospital in north India were evaluated for MetS. These patients were assessed on Health Promoting Lifestyle Profile scale II (HPLP II), World Health Organization QOL -Bref Version (WHOQOL-Bref), Impact of Weight on Quality of Life- Lite version (IWOQOL -Lite), Body weight, Image and Self-esteem Evaluation questionnaire (BWISE), Obesity-related Problem scale (OP scale) and Global Assessment of Functioning (GAF) scale.
MetS was associated with lower scores on domains of health responsibility and nutrition habit domain on HPLP-II scale in both groups, and additionally on physical activity and stress management domain in BPAD group. On WHOQOL-Bref, MetS was associated with lower scores on the domains of physical and psychological health in both groups. On IWQOL-Lite, scores on personal distress and self esteem domains were higher in those with obesity in both groups and also on physical activity domain in schizophrenia group. Those with MetS had lower level of functioning as measured by GAF in schizophrenia group. Fulfillment of higher number of criteria of MetS correlated with poorer quality of life and higher problems in both groups.
INTERPRETATION & CONCLUSIONS: Many modifiable lifestyle factors increase the risk of MetS. MetS was found to be associated with poorer QOL in patients with BPAD and schizophrenia; in addition, obesity led to poor self-esteem and excessive personal distress.
尽管有研究报告双相情感障碍（BPAD）和精神分裂症患者中代谢综合征的患病率较高，但关于其对患者生活影响的数据却很缺乏。本研究旨在评估与代谢综合征（MetS）相关的生活方式因素，并研究MetS对BPAD和精神分裂症患者功能及生活质量（QOL）的影响。
对印度北部一家三级护理医院产出单元的102例BPAD患者和72例精神分裂症患者进行了MetS评估。这些患者接受了健康促进生活方式量表II（HPLP II）、世界卫生组织生活质量简表（WHOQOL-Bref）、体重对生活质量的影响-简化版（IWOQOL-Lite）、体重、形象和自尊评估问卷（BWISE）、肥胖相关问题量表（OP量表）以及功能总体评估（GAF）量表的评估。
在两组中，MetS均与HPLP-II量表上的健康责任和营养习惯领域得分较低相关，在BPAD组中还与身体活动和压力管理领域得分较低相关。在WHOQOL-Bref量表上，MetS与两组的身体和心理健康领域得分较低相关。在IWOQOL-Lite量表上，两组肥胖患者在个人困扰和自尊领域的得分较高，精神分裂症组在身体活动领域的得分也较高。在精神分裂症组中，MetS患者的功能水平通过GAF测量较低。满足更多MetS标准与两组较差的生活质量和更多问题相关。
许多可改变的生活方式因素会增加MetS的风险。研究发现，MetS与BPAD和精神分裂症患者较差的生活质量相关；此外，肥胖会导致自尊低下和过度的个人困扰。
