Chang Chengyue, Zhu Shaowei, Xu Zhenkuan, Liu Yuguang
Department of Neurosurgery, Qilu Hospital, Brain Science Research Institute, Shandong University Jinan, Shandong, P. R. China.
Department of Neurology, Qilu Hospital, Shandong University Jinan, Shandong, P. R. China.
Int J Clin Exp Pathol. 2018 Feb 1;11(2):502-511. eCollection 2018.
Glioma is one of the most malignant tumor types worldwide. Despite great efforts made in surgery, imaging, chemotherapy, and radiation, the overall prognosis for patients with glioma remains poor. The pathogenesis of glioma is an urgent problem that must be solved. Tripartite motif-containing protein 37 (TRIM37) is an E3 ubiquitin ligase that may be involved in the tumorigenesis of several types of cancer; however, its expression pattern and biological functions in glioma remain unknown. Our previous studies indicated that the expression levels of TRIM37 were upregulated in glioma samples and were associated with a higher glioma grade. The present study demonstrates that suppression of TRIM37 by RNA-mediated interference inhibits the growth of glioma cells , which is associated with induction of apoptosis and cell cycle arrest, and with inhibition of migration and invasion. These results provide insights into understanding the role of TRIM37 in regulating the biological behavior of glioma cells and may indicate TRIM37 as a candidate target for the treatment of glioma.
胶质瘤是全球最恶性的肿瘤类型之一。尽管在手术、影像学、化疗和放疗方面付出了巨大努力，但胶质瘤患者的总体预后仍然很差。胶质瘤的发病机制是一个亟待解决的问题。含三联基序蛋白37（TRIM37）是一种E3泛素连接酶，可能参与多种癌症的肿瘤发生；然而，其在胶质瘤中的表达模式和生物学功能仍不清楚。我们之前的研究表明，TRIM37在胶质瘤样本中的表达水平上调，且与较高的胶质瘤分级相关。本研究表明，RNA介导的干扰抑制TRIM37可抑制胶质瘤细胞的生长，这与诱导凋亡和细胞周期停滞以及抑制迁移和侵袭有关。这些结果为理解TRIM37在调节胶质瘤细胞生物学行为中的作用提供了见解，并可能表明TRIM37是治疗胶质瘤的候选靶点。
