Nepal Gaurav, Rehrig Jessica Holly, Ojha Rajeev
Tribhuvan University Institute of Medicine Kathmandu Nepal.
University of New England College of Osteopathic Medicine Biddeford Maine USA.
Aging Med (Milton). 2019 Jul 23;2(3):174-183. doi: 10.1002/agm2.12075. eCollection 2019 Sep.
Dopaminergic neuronal degeneration seen in Parkinson's disease (PD) might result from a single nucleotide polymorphism (SNP) in the glutamate ionotropic receptor NMDA type subunit 2A () gene. We thus performed a meta-analysis exploring the relationship between the rs4998386 SNP of the gene and PD susceptibility.
We searched PubMed, EMBASE, Web of Science, Google Scholar, and China National Knowledge Infrastructure for studies published between January 2005 and January 2019. The association between the rs4998386 polymorphism and PD susceptibility was evaluated by calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs).
Meta-analysis results did not show a significant association between the rs4998386 polymorphism of the gene and PD susceptibility when assuming an allelic model (OR, 0.90; 95% CI, 0.76-1.07; = .22; = 53%), a dominant model (OR, 0.96; 95% CI, 0.82-1.12; = .62; = 64%), or a recessive model (OR, 1.14; 95% CI, 0.93-1.38; = .22; = 0%).
Our meta-analysis found that the rs4998386 polymorphism of the gene is not associated with risk of PD in either Europeans or white Americans. However, large sample studies with different ethnicities should be conducted to establish the role of the rs4998386 polymorphism in PD pathophysiology.
帕金森病（PD）中所见的多巴胺能神经元变性可能源于谷氨酸离子型受体NMDA 2A（GRIN2A）基因的单核苷酸多态性（SNP）。因此，我们进行了一项荟萃分析，以探究GRIN2A基因的rs4998386 SNP与PD易感性之间的关系。
我们检索了PubMed、EMBASE、科学网、谷歌学术和中国知网，查找2005年1月至2019年1月发表的研究。通过计算合并比值比（OR）和95%置信区间（CI）来评估rs4998386多态性与PD易感性之间的关联。
在等位基因模型（OR，0.90；95%CI，0.76 - 1.07；P = 0.22；I² = 53%）、显性模型（OR，0.96；95%CI，0.82 - 1.12；P = 0.62；I² = 64%）或隐性模型（OR，1.14；95%CI，0.93 - 1.38；P = 0.22；I² = 0%）下，荟萃分析结果均未显示GRIN2A基因的rs4998386多态性与PD易感性之间存在显著关联。
我们的荟萃分析发现，GRIN2A基因的rs4998386多态性与欧洲人或美国白人的PD风险无关。然而，应开展不同种族的大样本研究，以确定rs4998386多态性在PD病理生理学中的作用。
