Tribhuvan University Institute of Medicine, Kathmandu, Nepal.
Chengdu University of Information Technology, Chengdu, Sichuan, China.
Mol Genet Genomic Med. 2019 Jul;7(7):e00784. doi: 10.1002/mgg3.784. Epub 2019 Jun 3.
The intercellular adhesion molecule-1 (ICAM-1)/leukocyte function associated antigen-1 (LFA-1) adhesion system regulates leukocyte interactions, migration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis. Therefore, single nucleotide polymorphisms (SNPs) of the ICAM-1 gene may strongly influence the expression and biological activity of ICAM-1 and play a potentially important role in the pathogenesis of ischemic stroke. In the current meta-analysis, we investigated the relationship between the ICAM-1 gene K469E SNP and the risk of ischemic stroke.
Two investigators independently searched PubMed, Web of Science, Google Scholar, WANFANG, China National Knowledge Infrastructure (CNKI) and J-STAGE for studies published from January 2000 to February 2019 without language restriction. The association of K469E polymorphism and ischemic stroke in three genetic models (allelic, recessive, and dominant) were evaluated using Pooled odds ratios (ORs) with 95% confidence intervals (CIs).
Our study included 20 studies from four continents and four different countries, including 3,137 cases and 15,382 controls. Meta-analysis results did not show a significant association between K469E polymorphism of ICAM-1 gene and ischemic stroke when assuming allelic model (OR: 1.12; 95% CI: 0.8 to 1.55; p = 0.51; I = 93%) or recessive model (OR: 1.28; 95% CI: 0.89 to 1.84; p = 0.18; I = 82%) or dominant model (OR: 1.20; 95% CI: 0.92 to 1.56; p = 0.17; I = 85%). However, in all three genetic models, subgroup analysis revealed that the K469E polymorphism of the ICAM-1 gene is associated with ischemic stroke in the Caucasian population.
K469E polymorphism of ICAM-1 gene might be a risk factor for ischemic stroke in Caucasians, which suggested that K469E polymorphism might help in early identification of those at risk and help in primary prevention of ischemic stroke.
细胞间黏附分子-1（ICAM-1）/白细胞功能相关抗原-1（LFA-1）黏附系统调节白细胞相互作用、迁移和黏附，并且似乎在动脉粥样硬化和血栓形成中发挥重要作用。因此，ICAM-1 基因的单核苷酸多态性（SNP）可能强烈影响 ICAM-1 的表达和生物学活性，并在缺血性卒中的发病机制中发挥潜在的重要作用。在目前的荟萃分析中，我们研究了 ICAM-1 基因 K469E SNP 与缺血性卒中风险之间的关系。
两位研究者独立检索了从 2000 年 1 月至 2019 年 2 月发表的文献，无语言限制，检索数据库包括 PubMed、Web of Science、Google Scholar、WANFANG、中国国家知识基础设施（CNKI）和 J-STAGE。使用合并优势比（OR）及其 95%置信区间（CI）评估 K469E 多态性与三种遗传模型（等位基因、隐性和显性）下缺血性卒中的关系。
我们的研究纳入了来自四大洲四个不同国家的 20 项研究，包括 3137 例病例和 15382 例对照。当假设等位基因模型（OR：1.12；95%CI：0.8 至 1.55；p=0.51；I²=93%）或隐性模型（OR：1.28；95%CI：0.89 至 1.84；p=0.18；I²=82%）或显性模型（OR：1.20；95%CI：0.92 至 1.56；p=0.17；I²=85%）时，K469E 多态性与缺血性卒中之间均无显著相关性。然而，在所有三种遗传模型中，亚组分析显示，ICAM-1 基因的 K469E 多态性与白种人群中的缺血性卒中相关。
ICAM-1 基因的 K469E 多态性可能是白种人群中缺血性卒中的危险因素，这表明 K469E 多态性可能有助于早期识别高危人群，并有助于缺血性卒中的一级预防。
