Batzri S, Catravas G
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
Proc Soc Exp Biol Med. 1988 Nov;189(2):255-60. doi: 10.3181/00379727-189-2-rc1.
We evaluated the effect of a single dose of ionizing radiation on gastric secretion in awake guinea pigs equipped with a permanent gastric cannula. Changes in gastric secretion were measured using a dye dilution technique. Infusion of histamine increased acid and fluid output and there was a positive correlation (r = 0.93) between the two. Total body irradiation with 400 cGy, like cimetidine, suppressed acid and fluid secretion under basal conditions and during histamine stimulation by 50-90%. Recovery from the radiation damage was only partial after one week. Irradiation inhibited the rise in gastric juice volume during histamine stimulation and also reduced the normal gain in body weight of the guinea pig. These results demonstrate that ionizing radiations have an immediate and long lasting effects on the gastric mucosal function of the guinea pig.
我们评估了单次剂量的电离辐射对配备永久性胃插管的清醒豚鼠胃分泌的影响。采用染料稀释技术测量胃分泌的变化。输注组胺可增加酸和液体的分泌量，且两者之间存在正相关（r = 0.93）。400 cGy的全身照射，与西咪替丁一样，在基础条件下和组胺刺激期间可抑制酸和液体分泌50 - 90%。一周后辐射损伤仅部分恢复。辐射抑制了组胺刺激期间胃液量的增加，还降低了豚鼠正常的体重增加。这些结果表明，电离辐射对豚鼠胃黏膜功能有即刻且持久的影响。
