Medical Research & Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Medical Research & Biometrics Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Bone. 2020 Apr;133:115226. doi: 10.1016/j.bone.2020.115226. Epub 2020 Jan 13.
This multicenter study aimed to evaluate the association between volumetric bone mineral density (vBMD) and abdominal aortic calcification (AAC) in a Chinese population.
Quantitative computed tomography (QCT) and Agatston score (AS) were used to measure vBMD and AAC, respectively, in 3457 participants during 2013-2017. The association between vBMD and AAC was assessed using multivariate regression analysis, adjusted for age, residence, education, body mass index, and other cardiovascular risk factors.
The mean age of women and men was 61.4 and 62.7 years, respectively. In total, 30.4% of women and 37.7% of men were found to have AAC. After full adjustment, higher vBMD was associated with lower AAC score (β, -0.095; 95% confidence interval [CI], -0.167 to -0.024; P = 0.0087) and lower AAC prevalence (odds ratio [OR], 0.873; 95% CI, 0.824 to 0.924; P < 0.0001) in men. Inverse trends were also observed in the association of vBMD quartile with AAC severity (lowest vs highest quartile; β = 0.235; 95% CI, 0.011 to 0.459; P < 0.0001) and AAC prevalence (lowest vs highest quartile; OR = 1.329; 95% CI, 1.087 to 1.625; P < 0.0001) in men. However, no significant result was obtained in women, except for the association between quartiles of vBMD and AAC score.
In our study, vBMD was inversely associated with AAC among men independent of age and shared risk factors. However, the association was not significant among women.
本多中心研究旨在评估中国人群中容积骨密度（vBMD）与腹主动脉钙化（AAC）之间的关联。
在 2013 年至 2017 年期间，对 3457 名参与者使用定量计算机断层扫描（QCT）和 Agatston 评分（AS）分别测量 vBMD 和 AAC。使用多元回归分析评估 vBMD 与 AAC 之间的关联，并调整年龄、居住地点、教育程度、体重指数和其他心血管危险因素。
女性和男性的平均年龄分别为 61.4 岁和 62.7 岁。共有 30.4%的女性和 37.7%的男性存在 AAC。经过充分调整后，较高的 vBMD 与较低的 AAC 评分（β，-0.095；95%置信区间[CI]，-0.167 至-0.024；P=0.0087）和较低的 AAC 患病率（比值比[OR]，0.873；95%CI，0.824 至 0.924；P<0.0001）相关。在男性中，vBMD 四分位数与 AAC 严重程度（最低四分位与最高四分位相比；β，0.235；95%CI，0.011 至 0.459；P<0.0001）和 AAC 患病率（最低四分位与最高四分位相比；OR，1.329；95%CI，1.087 至 1.625；P<0.0001）之间也存在类似的关联。然而，在女性中，除了 vBMD 四分位数与 AAC 评分之间的关联外，没有得到显著结果。
在本研究中，vBMD 与男性的 AAC 独立于年龄和共同的危险因素呈负相关。然而，在女性中这种关联并不显著。
