Kuipers A L, Zmuda J M, Carr J J, Terry J G, Patrick A L, Ge Y, Hightower R C, Bunker C H, Miljkovic I
Department of Epidemiology, University of Pittsburgh, 130 DeSoto St, A521 Crabtree Hall, Pittsburgh, PA, 15261, USA,
Osteoporos Int. 2014 Mar;25(3):1063-9. doi: 10.1007/s00198-013-2486-3. Epub 2013 Aug 22.
We tested for association between cortical and trabecular volumetric bone mineral density (vBMD) with abdominal aortic calcification (AAC) prevalence in 278 Afro-Caribbean men. AAC was present in 68.3 % of the men. Greater cortical, but not trabecular, vBMD was associated with significantly decreased odds of AAC independent of traditional risk factors.
The aim of this study is to assess the prevalence and correlates of AAC in a sample of 278 Afro-Caribbean men (mean age 56) and to test for a largely unexplored association between cortical and trabecular vBMD with AAC prevalence.
Men were recruited consecutively as part of an ongoing prospective cohort study of body composition in men aged 40+. For this analysis, AAC was assessed by computed tomography of the abdomen from L3 to S1. Aortic calcium was scored using the Agatston method, and prevalence was defined as a score ≥10 to rule out false positives. Men also had BMD assessed using peripheral quantitative computed tomography at 4 % (trabecular vBMD) and 33 % (cortical vBMD) of the radius and tibia.
Abdominal aortic calcification was present in 68.3 % of the men. Significant independent predictors of AAC prevalence were increased age, increased BMI, hypertension, and current smoking. Age was the strongest predictor, with each SD (7.8 year) increase in age conferring 2.7 times increased odds of having AAC (P < 0.0001). A one SD greater cortical, but not trabecular, vBMD was associated with a significant decreased odds of AAC prevalence independent of other traditional risk factors (OR 0.65; 95 % CI 0.45-0.92).
Cortical vBMD is inversely associated with AAC presence. This finding suggests that there may be shared physiology between cortical bone compartment remodeling and vascular calcification.
我们在278名非洲裔加勒比男性中测试了皮质骨和小梁骨体积骨密度（vBMD）与腹主动脉钙化（AAC）患病率之间的关联。68.3%的男性存在腹主动脉钙化。更高的皮质骨而非小梁骨vBMD与腹主动脉钙化几率显著降低相关，且不受传统风险因素影响。
本研究的目的是评估278名非洲裔加勒比男性（平均年龄56岁）样本中腹主动脉钙化的患病率及其相关因素，并测试皮质骨和小梁骨vBMD与腹主动脉钙化患病率之间尚未充分探索的关联。
作为一项正在进行的40岁以上男性身体成分前瞻性队列研究的一部分，连续招募男性。对于本分析，通过对L3至S1腹部进行计算机断层扫描评估腹主动脉钙化。使用阿加斯顿方法对主动脉钙化进行评分，患病率定义为评分≥10以排除假阳性。男性还使用外周定量计算机断层扫描在桡骨和胫骨的4%（小梁骨vBMD）和33%（皮质骨vBMD）处评估骨密度。
68.3%的男性存在腹主动脉钙化。腹主动脉钙化患病率的显著独立预测因素是年龄增加、体重指数增加、高血压和当前吸烟。年龄是最强的预测因素，年龄每增加一个标准差（7.8岁），腹主动脉钙化的几率增加2.7倍（P < 0.0001）。皮质骨vBMD每增加一个标准差而非小梁骨vBMD，与腹主动脉钙化患病率几率显著降低相关，且不受其他传统风险因素影响（OR 0.65；95%CI 0.45 - 0.92）。
皮质骨vBMD与腹主动脉钙化的存在呈负相关。这一发现表明皮质骨重塑和血管钙化之间可能存在共同的生理机制。
