Hu Tingting, Yang Xingyuan, Gao Lei, Liu Ying, Zhang Wei, Wang Yan, Zhu Xiaona, Liu Xiangdong, Liu Hongran, Ma Xiaohui
Department of Radiology, Hebei Medical University Third Hospital, No. 139 Ziqiang Street, Qiaoxi District, Shijiazhaung, Hebei, 050051, China.
Department of CT/MRI, Hebei Medical University Third Hospital, No. 139 Ziqiang Street, Qiaoxi District, Shijiazhaung, Hebei, 050051, China.
BMC Med Imaging. 2023 Oct 6;23(1):149. doi: 10.1186/s12880-023-01115-1.
To explore the feasibility of low-dose computed tomography (LDCT) with asynchronous quantitative computed tomography (asynchronous QCT) for assessing the volumetric bone mineral density (vBMD).
416 women patients, categorized into 4 groups, were included and underwent chest CT examinations combined with asynchronous QCT, and CT scanning dose protocols (LDCT or CDCT) were self-determined by the participants. Radiation dose estimations were retrieved from patient protocols, including volume CT dose index (CTDIvol) and dose-length-product (DLP), and then calculated effective dose (ED). Delimiting ED by 1.0 mSv, chest CT examinations were categorized into 2 groups, LDCT group and CDCT group. vBMD of T12-L2 was obtained by transferring the LDCT and CDCT images to the QCT workstation, without extra radiation.
There was no difference of vBMD among 4 age groups in LDCT group (P = 0.965), and no difference in CDCT group (P = 0.988). In LDCT group and CDCT group, vBMD was not correlated to mAs, CTDIvol and DLP (P > 0.05), respectively. Between LDCT group and CDCT group, there was no difference of vBMD (P ≥ 0.480), while differences of mAs, CTDIvol and DLP.
There was no difference of vBMD between LDCT group and CDCT group and vBMD was not correlated to mAs. While screening for diseases such as lung cancer and mediastinal lesions, LDCT combined with asynchronous QCT can be also used to assess vBMD simultaneously with no extra imaging equipment, patient visit time, radiation dose and no additional economic cost.
探讨低剂量计算机断层扫描（LDCT）联合异步定量计算机断层扫描（asynchronous QCT）评估体积骨密度（vBMD）的可行性。
纳入416例女性患者，分为4组，进行胸部CT检查并联合异步QCT，CT扫描剂量方案（LDCT或CDCT）由参与者自行决定。从患者方案中获取辐射剂量估计值，包括容积CT剂量指数（CTDIvol）和剂量长度乘积（DLP），然后计算有效剂量（ED）。以1.0 mSv为界划分ED，将胸部CT检查分为2组，即LDCT组和CDCT组。将LDCT和CDCT图像传输至QCT工作站获取T12-L2的vBMD，无需额外辐射。
LDCT组4个年龄组的vBMD无差异（P = 0.965），CDCT组也无差异（P = 0.988）。在LDCT组和CDCT组中，vBMD分别与mAs、CTDIvol和DLP均无相关性（P > 0.05）。LDCT组和CDCT组之间，vBMD无差异（P≥0.480），而mAs、CTDIvol和DLP有差异。
LDCT组和CDCT组的vBMD无差异，且vBMD与mAs无相关性。在筛查肺癌和纵隔病变等疾病时，LDCT联合异步QCT还可在不增加额外成像设备、患者就诊时间、辐射剂量及无额外经济成本的情况下同时评估vBMD。
