Aghababaie Zahra, Chan Chih-Hsiang Alexander, Paskaranandavadivel Niranchan, Beyder Arthur, Farrugia Gianrico, Asirvatham Samuel, O'Grady Gregory, Cheng Leo K, Angeli Timothy R
Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:170-173. doi: 10.1109/EMBC.2019.8856406.
The interstitial cells of Cajal (ICC) initiate, coordinate and propagate bioelectrical slow wave activity that drives gastric motility. In the healthy human stomach, slow wave activity is highly organized. Gastric motility disorders are associated with dysrhythmias. While ablation is widely used to treat cardiac dysrhythmias, this approach has yet to be trialed in the stomach. In this study, radiofrequency (RF) ablation was applied in pig stomachs in vivo to create targeted electrical conduction blocks. Ablations were performed at temperature control mode (55-70°C), and resultant conduction blocks were identified and verified using high-resolution electrical mapping. Termination of slow wave propagation at ablation sites was confirmed by a decrease in extracellular slow wave amplitude from 1.7 ± 0.2 mV to an undetectable amplitude, as well as spatiotemporal pattern analysis of conduction blocks. The use of high-resolution electrical mapping can now be employed to investigate ablation as a potential therapy for gastric dysrhythmias in motility disorders.
Cajal间质细胞（ICC）启动、协调和传播驱动胃动力的生物电慢波活动。在健康人的胃中，慢波活动高度有序。胃动力障碍与心律失常有关。虽然消融术广泛用于治疗心脏心律失常，但这种方法尚未在胃中进行试验。在本研究中，在猪的活体胃中应用射频（RF）消融术以创建靶向性电传导阻滞。在温度控制模式（55 - 70°C）下进行消融，并使用高分辨率电图识别和验证产生的传导阻滞。通过细胞外慢波幅度从1.7±0.2 mV降至不可检测的幅度以及传导阻滞的时空模式分析，证实了消融部位慢波传播的终止。现在可以使用高分辨率电图来研究消融术作为动力障碍性胃心律失常的潜在治疗方法。
