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Nonsense suppressors of yeast cause osmotic-sensitive growth.酵母的无义抑制子会导致对渗透压敏感的生长。
Proc Natl Acad Sci U S A. 1977 Jan;74(1):305-9. doi: 10.1073/pnas.74.1.305.
2
Inhibition of growth by amber suppressors in yeast.酵母中琥珀抑制基因对生长的抑制作用。
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Patterns of Genetic and Phenotypic Suppression of lys2 Mutations in the Yeast SACCHAROMYCES CEREVISIAE.酵母 SACCHAROMYCES CEREVISIAE 中 lys2 突变的遗传和表型抑制模式。
Genetics. 1979 Sep;93(1):67-79. doi: 10.1093/genetics/93.1.67.
4
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J Mol Biol. 1979 Feb 15;128(1):81-100. doi: 10.1016/0022-2836(79)90309-7.
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A temperature-sensitive mutant of Escherichia coli that shows enhanced misreading of UAG/A and increased efficiency for some tRNA nonsense suppressors.一种大肠杆菌的温度敏感突变体，其对UAG/A的错读增强，并且某些tRNA无义抑制子的效率提高。
Mol Gen Genet. 1984;193(1):38-45. doi: 10.1007/BF00327411.
6
Isolation and characterization of amber suppressors in yeast.酵母中琥珀抑制子的分离与鉴定
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7
Genetic analysis of a transposable suppressor gene in Saccharomyces cerevisiae.酿酒酵母中转座抑制基因的遗传分析。
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4623-7. doi: 10.1073/pnas.73.12.4623.
8
Recessive UAA suppressors of the yeast Saccharomyces cerevisiae.酿酒酵母的隐性UAA抑制基因
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9
An homologous in vitro assay for yeast nonsense suppressors.一种用于酵母无义抑制子的同源体外测定法。
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10
Characterization of amber and ochre suppressors in Salmonella typhimurium.鼠伤寒沙门氏菌中琥珀突变和赭石突变抑制基因的特性分析。
J Bacteriol. 1979 Jan;137(1):433-9. doi: 10.1128/jb.137.1.433-439.1979.

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Mutation of the non-Mendelian suppressor, Psi, in yeast by hypertonic media.高渗培养基对酵母中非孟德尔抑制因子Psi的诱变。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1952-6. doi: 10.1073/pnas.76.4.1952.
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The tRNA-Tyr gene family of Saccharomyces cerevisiae: agents of phenotypic variation and position effects on mutation frequency.酿酒酵母的tRNA-Tyr基因家族：表型变异的因素及对突变频率的位置效应
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Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae.基因过表达作为一种工具，用于鉴定酿酒酵母中参与翻译终止的新反式作用因子。
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Alanine-scanning mutagenesis of protein phosphatase type 1 in the yeast Saccharomyces cerevisiae.酿酒酵母中1型蛋白磷酸酶的丙氨酸扫描诱变
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Suppressors of thermosensitive mutations in the DNA polymerase delta gene of Saccharomyces cerevisiae.酿酒酵母DNA聚合酶δ基因中温度敏感突变的抑制子
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10
Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.对因一种因子和α因子信息素而对G1期阻滞超敏感的酿酒酵母突变体的分离与遗传分析。
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本文引用的文献

1
Temperature-sensitive, osmotic-remedial mutants of Neurospora crassa: osmotic pressure induced alterations of enzyme stability.粗糙脉孢菌的温度敏感型、渗透压修复突变体：渗透压诱导的酶稳定性改变
Mol Gen Genet. 1975;136(1):31-40. doi: 10.1007/BF00275446.
2
OSMOTIC-REMEDIAL MUTANTS. A NEW CLASSIFICATION FOR NUTRITIONAL MUTANTS IN YEAST.渗透补救突变体。酵母营养突变体的一种新分类。
Genetics. 1964 Nov;50(5):829-39. doi: 10.1093/genetics/50.5.829.
3
RESPIRATION-DEFICIENT MUTANTS OF YEAST. II. BIOCHEMISTRY.酵母的呼吸缺陷型突变体。II. 生物化学
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STREPTOMYCIN, SUPPRESSION, AND THE CODE.链霉素、抑制作用与密码子
Proc Natl Acad Sci U S A. 1964 May;51(5):883-90. doi: 10.1073/pnas.51.5.883.
5
Repair of multiple defects of a regulatory mutant of Neurospora by high osmotic pressure and by reversion.通过高渗透压和回复作用修复粗糙脉孢菌调节突变体的多个缺陷。
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A recessive lethal super-suppressor mutation in yeast and other psi phenomena.酵母中的一种隐性致死超级抑制突变及其他ψ现象。
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7
Amino acid replacements resulting from super-suppression of nonsense mutants of iso-1-cytochrome c from yeast.酵母异-1-细胞色素c无义突变体的超抑制所导致的氨基酸替换。
J Mol Biol. 1971 Oct 14;61(1):157-73. doi: 10.1016/0022-2836(71)90213-0.
8
Informational suppression.信息抑制
Annu Rev Genet. 1970;4:107-34. doi: 10.1146/annurev.ge.04.120170.000543.
9
Suppressors in yeast.酵母中的抑制因子。
Curr Top Microbiol Immunol. 1974;64(0):1-47. doi: 10.1007/978-3-642-65848-8_1.
10
Antisuppressors in yeast.酵母中的抗抑制因子。
Mol Gen Genet. 1973 Aug 28;124(4):305-20. doi: 10.1007/BF00267660.

酵母的无义抑制子会导致对渗透压敏感的生长。

Nonsense suppressors of yeast cause osmotic-sensitive growth.

作者信息

Singh A

出版信息

Proc Natl Acad Sci U S A. 1977 Jan;74(1):305-9. doi: 10.1073/pnas.74.1.305.

DOI:10.1073/pnas.74.1.305
PMID:319459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC393248/
Abstract

Many nonsense suppressors of Saccharomyces cerevisiae cause growth inhibition on hypertonic media. Eight tyrosine-inserting UAA (ochre) suppressors, eight tyrosine-inserting UAG (amber) suppressors, a leucine-inserting UAG suppressor, and a serine-inserting recessive lethal UAG suppressor cause osmotic sensitivity, whereas a serine-inserting UAA suppressor does not cause sensitivity. Although the mechanism is not understood, the growth inhibition of specific suppressors on hypertonic media is correlated with their efficiencies of suppression. This heretofore unknown property of nonsense suppressors is useful for mitotic mapping, selecting tRNA mutants, selecting antisuppressors, and scoring nonsense suppressors.

摘要

酿酒酵母的许多无义抑制子会导致在高渗培养基上生长受抑制。八个插入酪氨酸的UAA（赭石型）抑制子、八个插入酪氨酸的UAG（琥珀型）抑制子、一个插入亮氨酸的UAG抑制子以及一个插入丝氨酸的隐性致死UAG抑制子会导致渗透敏感性，而一个插入丝氨酸的UAA抑制子不会导致敏感性。尽管其机制尚不清楚，但特定抑制子在高渗培养基上的生长抑制与其抑制效率相关。无义抑制子这种此前未知的特性可用于有丝分裂作图、筛选tRNA突变体、筛选反抑制子以及对无义抑制子进行评分。