酿酒酵母中转座抑制基因的遗传分析。
Genetic analysis of a transposable suppressor gene in Saccharomyces cerevisiae.
作者信息
Laten H M, Gorman J, Webb F, Bock R M
出版信息
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4623-7. doi: 10.1073/pnas.73.12.4623.
Abstract
We have demonstrated in Saccharomyces cerevisiae the transposition of a gene coding for an efficient ochre (UAA) suppressor from a centromere-linked site on chromosome III to two new sites in the yeast genome. One site is on chromosome VI, very close to, if not allelic with, SUP11, one of eight genes coding for a tyrosine-inserting suppressor. The second site is on chromosome III, unlinked to the centromere and distal to the mating type locus. This site is very close to those mapped for the recessive lethal amber suppressors, SUP-RL1 and SUP61.
摘要
我们已在酿酒酵母中证明，一个编码高效赭石型（UAA）抑制基因从位于第三条染色体上与着丝粒相连的位点转座至酵母基因组中的两个新位点。一个位点在第六条染色体上，即使与编码酪氨酸插入抑制基因的八个基因之一SUP11不是等位基因，也与之非常接近。第二个位点在第三条染色体上，与着丝粒不连锁且位于交配型基因座的远端。该位点与隐性致死琥珀型抑制基因SUP-RL1和SUP61的定位位点非常接近。
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