Thanaj Marjola, Chipperfield Andrew J, Clough Geraldine F
Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:2281-2284. doi: 10.1109/EMBC.2019.8856856.
Attractor reconstruction analysis has been previously used to determine changes in the shape and variability of fairly periodic signals such as arterial blood pressure signals and electroencephalogram signals, providing a two-dimensional attractor with features like density and symmetry. Since BF signals are fairly periodic and quasi-stationary, we set out to investigate whether attractor reconstruction method could be applied in signals derived from the microvascular perfusion. We describe the basis and the implementation of attractor reconstruction analysis of the microvascular blood flux (BF) signals recorded from the skin of 15 healthy male volunteers, age 29.2 ± 8.1y (mean ± SD). The efficacy of attractor reconstruction analysis (ARA) as a potential method of identifying changes in the microvascular function is evaluated in two haemodynamic steady states, at 33°C, and during warming at 43°C to generate a local thermal hyperaemia (LTH). Our findings show a significant drop of the maximal density derived from the ARA, during increased flow and that there was good discrimination of the blood flow signals between the two haemodynamic steady states, having good classification accuracy (80%). This study shows that ARA of BF signals can identify different microvascular functional states and thus has a potential for the clinical assessment and diagnosis of pathophysiological condition.
吸引子重构分析此前已被用于确定相当周期性信号（如动脉血压信号和脑电图信号）的形状和变异性变化，提供具有密度和对称性等特征的二维吸引子。由于脑血流信号相当周期性且准平稳，我们着手研究吸引子重构方法是否可应用于微血管灌注衍生的信号。我们描述了从15名年龄为29.2±8.1岁（均值±标准差）的健康男性志愿者皮肤记录的微血管血流量（BF）信号吸引子重构分析的基础和实施过程。在33°C的两种血流动力学稳态以及在43°C升温以产生局部热充血（LTH）期间，评估吸引子重构分析（ARA）作为识别微血管功能变化的潜在方法的功效。我们的研究结果表明，在血流增加期间，ARA得出的最大密度显著下降，并且在两种血流动力学稳态之间对血流信号有良好的区分，具有良好的分类准确率（80%）。这项研究表明，BF信号的ARA可以识别不同的微血管功能状态，因此在病理生理状况的临床评估和诊断方面具有潜力。
