Máková Veronika, Holubová Barbora, Tetour David, Brus Jiří, Řezanka Michal, Rysová Miroslava, Hodačová Jana
Department of Nanomaterials in Natural Science, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, 461 17 Liberec, Czech Republic.
Department of Organic Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague, Czech Republic.
Polymers (Basel). 2020 Jan 14;12(1):206. doi: 10.3390/polym12010206.
An urgent need to find an effective solution to bacterial resistance is pushing worldwide research for highly effective means against this threat. Newly prepared hybrid organosilane fibres consisting of a (1,2)-cyclohexane-1,2-diamine derivative, interconnected in the fibre network via covalent bonds, were fully characterised via different techniques, including FTIR, TGA-FTIR, SEM-EDS, and solid-state NMR. Fibrous samples were successfully tested against two types of pathogenic bacterial strains, namely , and . The obtained results, showing >99.9% inhibition against and in direct contact compared to the control, may help particularly in case of infections, where there is an urgent need to treat the infection in direct contact. From this point of view, the above-mentioned fibrous material may find application in wound healing. Moreover, this new material has a positive impact on fibroblasts viability.
迫切需要找到一种有效的解决细菌耐药性的方法，这推动了全球范围内对抵御这种威胁的高效手段的研究。新制备的由（1,2）-环己烷-1,2-二胺衍生物组成的杂化有机硅烷纤维，通过共价键在纤维网络中相互连接，通过包括傅里叶变换红外光谱（FTIR）、热重-傅里叶变换红外光谱（TGA-FTIR）、扫描电子显微镜-能谱分析（SEM-EDS）和固态核磁共振（solid-state NMR）在内的不同技术进行了全面表征。纤维样品成功地针对两种致病细菌菌株进行了测试，即 ，以及 。与对照相比，所获得的结果表明对 和 的直接接触抑制率>99.9%，这在急需直接治疗感染的情况下可能特别有帮助。从这个角度来看，上述纤维材料可能在伤口愈合中找到应用。此外，这种新材料对成纤维细胞的活力有积极影响。
