St Catherine Specialty Hospital, 10000 Zagreb & 49210 Zabok, Croatia.
University of Split School of Medicine, 21 000 Split, Croatia.
Pharmacogenomics. 2020 Jan;21(2):141-156. doi: 10.2217/pgs-2019-0134. Epub 2020 Jan 17.
Pharmacogenomics (PGx) is one of the core elements of personalized medicine. PGx information reduces the likelihood of adverse drug reactions and optimizes therapeutic efficacy. St Catherine Specialty Hospital in Zagreb/Zabok, Croatia has implemented a personalized patient approach using the RightMed Comprehensive PGx panel of 25 pharmacogenes plus Facor V Leiden, Factor II and MTHFR genes, which is interpreted by a special counseling team to offer the best quality of care. With the advent of significant technological advances comes another challenge: how can we harness the data to inform clinically actionable measures and how can we use it to develop better predictive risk models? We propose to apply the principles artificial intelligence to develop a medication optimization platform to prevent, manage and treat different diseases.
药物基因组学（PGx）是个性化医学的核心要素之一。PGx 信息可降低药物不良反应的可能性，并优化治疗效果。克罗地亚萨格勒布/扎博克的圣凯瑟琳专业医院采用了个性化的患者方法，使用了 25 个药物基因组加上 Factor V Leiden、Factor II 和 MTHFR 基因的 RightMed 综合 PGx 面板，由专门的咨询团队进行解释，以提供最佳的护理质量。随着重大技术进步的出现，又带来了另一个挑战：我们如何利用这些数据提供临床可行的措施，以及如何利用它来开发更好的预测风险模型？我们建议应用人工智能原理来开发一个药物优化平台，以预防、管理和治疗各种疾病。
