Votiakov V I, Gribkova N V, Kazak N F, Podol'skaia I A
Vopr Virusol. 1982 Mar-Apr;27(2):169-72.
The effect of 2-[1'-aminoethyl)-bicyclo[2.2.1]heptane chlorohydrate on the accumulation of hemagglutinating activity of chick embryo fibroblasts infected with influenza A/FPV/Rostock/34 (Hav1N1) and A/WSN/33 (H0N1) was studied. The drug inhibited hemagglutinines accumulation when added at various intervals after infection, the maximum effect having been observed upon its addition to the maintenance medium immediately after adsorption. Polyacrylamide gel electrophoresis showed the drug to reduce the synthesis of virus-specific proteins of A/FPV and to inhibit considerably the transcriptase activity of A/FPV and A/WSN viruses in vitro.
研究了2-[(1'-氨基乙基)-双环[2.2.1]庚烷]氯水合物对感染甲型流感病毒A/FPV/Rostock/34（Hav1N1）和A/WSN/33（H0N1）的鸡胚成纤维细胞血凝活性积累的影响。在感染后的不同时间间隔添加该药物时，其抑制血凝素的积累，在吸附后立即添加到维持培养基中时观察到最大效果。聚丙烯酰胺凝胶电泳显示该药物可减少A/FPV病毒特异性蛋白的合成，并在体外显著抑制A/FPV和A/WSN病毒的转录酶活性。
