Putuo District People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Biogerontology. 2020 Apr;21(2):245-256. doi: 10.1007/s10522-020-09857-z. Epub 2020 Jan 20.
Coix seed oil (CSO) has many beneficial effects, but there is limited research on its influence on the processes and mechanisms related to senescence. Here, we used Caenorhabditis elegans as an in vivo model to investigate CSO's bioeffects on longevity. CSO (1 mg/mL) significantly extended the mean lifespan of C. elegans by over 22.79% and markedly improved stress resistance. Gene-specific mutant studies showed that the CSO-mediated increase in life expectancy was dependent on mev-1, hsf-1 and daf-16, but not daf-2. Furthermore, CSO significantly upregulated stress-inducible genes, including daf-16 and its downstream genes (sod-3, hsp-16.2 and gst-4). In addition, four major fatty acids, linoleic, oleic, palmitic and stearic, played leading roles in C. elegans' extended lifespan. Thus, CSO increased the life expectancy of, and enhanced the stress resistance in, C. elegans mainly through daf-16 and its downstream genes, but not through the insulin/insulin-like growth factor 1 signaling pathway.
薏苡仁油（CSO）具有许多有益的作用，但关于其对衰老相关过程和机制的影响的研究有限。在这里，我们使用秀丽隐杆线虫作为体内模型来研究 CSO 对长寿的生物效应。CSO（1mg/mL）可使秀丽隐杆线虫的平均寿命延长超过 22.79%，并显著提高其应激抗性。基因特异性突变研究表明，CSO 介导的预期寿命增加依赖于 mev-1、hsf-1 和 daf-16，但不依赖于 daf-2。此外，CSO 还显著地上调应激诱导基因，包括 daf-16 及其下游基因（sod-3、hsp-16.2 和 gst-4）。此外，四种主要脂肪酸，亚油酸、油酸、棕榈酸和硬脂酸，在秀丽隐杆线虫的延长寿命中起主要作用。因此，CSO 主要通过 daf-16 及其下游基因而不是胰岛素/胰岛素样生长因子 1 信号通路来提高秀丽隐杆线虫的预期寿命并增强其应激抗性。
