血清白细胞介素37水平与瘢痕疙瘩严重程度之间的相关性。
Correlation between serum IL 37 levels with keloid severity.
作者信息
Khattab Fathia M, Samir Mai A
机构信息
Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
出版信息
J Cosmet Dermatol. 2020 Sep;19(9):2428-2431. doi: 10.1111/jocd.13290. Epub 2020 Jan 21.
BACKGROUND
Keloids are dermal fibroproliferative disorders that characterized by over deposition of components of the extracellular matrix. Interleukin 37 (IL-37) is known by its ability to inhibit the proliferation of keloid fibroblasts by inhibiting extracellular matrix production induced by transforming growth factor β (TGF-β). Thus, Il-37 is suggested to be used as an early preventive treatment for keloids.
AIMS
This study aimed to evaluate the correlation between serum levels of IL37 level and the keloid severity.
PATIENTS/METHODS: This is a cross-sectional analytic study involving thirty-two patients diagnosed clinically as having Keloid. An assessment of keloid severity was conducted by using Vancouver Scar Scale (VSS). Blood samples were collected from every patient to measure and assess the serum levels of IL37.
RESULTS
A negative correlation was found between IL37 level and the keloid severity (P = .0001; r = -.737). Also, there was a nonsignificant correlation between IL37 levels in patient with keloid and age, gender, duration of lesions, and family history.
CONCLUSION
Lower level of plasma IL 37 could be an indicator of the severity of Keloids.
背景
瘢痕疙瘩是一种皮肤纤维增生性疾病，其特征是细胞外基质成分过度沉积。白细胞介素37（IL-37）因其能够通过抑制转化生长因子β（TGF-β）诱导的细胞外基质产生来抑制瘢痕疙瘩成纤维细胞的增殖而为人所知。因此，IL-37被建议用作瘢痕疙瘩的早期预防性治疗药物。
目的
本研究旨在评估血清IL-37水平与瘢痕疙瘩严重程度之间的相关性。
患者/方法：这是一项横断面分析研究，纳入了32例临床诊断为瘢痕疙瘩的患者。采用温哥华瘢痕量表（VSS）对瘢痕疙瘩的严重程度进行评估。采集每位患者的血样以测量和评估血清IL-37水平。
结果
发现IL-37水平与瘢痕疙瘩严重程度呈负相关（P = .0001；r = -.737）。此外，瘢痕疙瘩患者的IL-37水平与年龄、性别、病程和家族史之间无显著相关性。
结论
血浆IL-37水平降低可能是瘢痕疙瘩严重程度的一个指标。
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