School of Chemical and Physical Sciences and Centre for Biodiscovery , Victoria University of Wellington , Wellington 6012 , New Zealand.
Maurice Wilkins Centre for Molecular Biodiscovery , Auckland 1142 , New Zealand.
J Nat Prod. 2020 Feb 28;83(2):547-551. doi: 10.1021/acs.jnatprod.9b01231. Epub 2020 Jan 21.
Marine organisms are a valuable source of bioactive natural products, yet bryozoan invertebrates have been relatively understudied. Herein, we report nelliellosides A and B, new secondary metabolites of the Pacific bryozoan , found using NMR-guided isolation. Their structures, including absolute configurations, were elucidated using spectroscopic and chromatographic techniques. Total synthesis of the natural products and four analogues was also achieved, in addition to an assessment of their biological activity, especially kinase inhibition.
海洋生物是生物活性天然产物的宝贵来源，但苔藓动物门无脊椎动物的研究相对较少。本文报道了太平洋苔藓动物中新的次生代谢产物内利埃洛昔苷 A 和 B，通过 NMR 指导的分离方法发现。采用光谱和色谱技术阐明了它们的结构，包括绝对构型。还实现了天然产物和四个类似物的全合成，并评估了它们的生物活性，特别是激酶抑制作用。
