ENT-Head and Neck Surgery Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK.
Clinical Oncology Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Hammersmith, London, UK.
Otolaryngol Head Neck Surg. 2020 Mar;162(3):267-268. doi: 10.1177/0194599820902043. Epub 2020 Jan 21.
The improved survival in patients with HPV-positive (human papilloma virus) oropharyngeal squamous cell carcinoma as compared with HPV-negative disease calls for treatment that preserves quality of life, particularly a functional swallow. There are several trials currently assessing treatment de-escalation in terms of less invasive transoral robotic surgery, reduced-dose radiotherapy, and omission of chemotherapy in this disease cohort. It is important for head and neck oncology surgeons to stay abreast of developments in this area to offer their patients the most up-to-date treatment and consider recruiting patients to trials at their institutions. For this purpose, we provide a summary of current trials and associated challenges in managing a disease with fast-evolving treatment algorithms.
与 HPV 阴性疾病相比，HPV 阳性（人乳头瘤病毒）口咽鳞状细胞癌患者的生存率得到了提高，这需要保留生活质量的治疗方法，特别是要有正常的吞咽功能。目前有几项临床试验正在评估在该疾病队列中减少侵袭性经口机器人手术、减少放疗剂量和省略化疗等治疗降级的方法。头颈部肿瘤外科医生了解这一领域的最新进展非常重要，以便为患者提供最新的治疗方法，并考虑在自己的机构招募患者参加临床试验。为此，我们总结了目前的临床试验和在管理具有快速发展治疗方案的疾病方面的相关挑战。
