Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Curr Biol. 2020 Jan 20;30(2):R89-R91. doi: 10.1016/j.cub.2019.11.087.
Amino acid signaling through the Rag GTPases promotes mTORC1 lysosomal localization and subsequent activation. Two new cryo-EM structures examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.
氨基酸通过 Rag GTPases 信号促进 mTORC1 溶酶体定位和随后的激活。两个新的冷冻电镜结构研究了 Rag GTPase 异二聚体与 mTORC1 复合物的结构。
