雷帕霉素靶蛋白复合物 1（mTORC1）的 Rag GTPases 调节机制。
Regulation of mTORC1 by the Rag GTPases.
机构信息
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, U.S.A.
Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, U.S.A.
出版信息
Biochem Soc Trans. 2023 Apr 26;51(2):655-664. doi: 10.1042/BST20210038.
The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator of cell growth. mTORC1 hyperactivation is observed in multiple diseases such as cancer, obesity, metabolic disorders, and neurodegeneration. The Rag GTPases sense amino acid levels and form heterodimers, where RagA or RagB binds to RagC or RagD, to recruit mTORC1 to the lysosome where it becomes activated. Here, we review amino acid signaling to mTORC1 through the Rag GTPases.
Rag GTPases 是一个进化上保守的家族，在哺乳动物雷帕霉素靶蛋白复合物 1（mTORC1）的氨基酸感应中发挥着关键作用。mTORC1 通常被称为细胞生长的主调控因子。mTORC1 的过度激活在多种疾病中都有观察到，如癌症、肥胖、代谢紊乱和神经退行性疾病。 Rag GTPases 感知氨基酸水平并形成异二聚体，其中 RagA 或 RagB 与 RagC 或 RagD 结合，将 mTORC1 募集到溶酶体，使其被激活。在这里，我们综述了 Rag GTPases 通过氨基酸信号传递到 mTORC1 的过程。
Zotero 插件