Department of Physics, Oakland University, Rochester, Michigan 48309, USA.
Phys Rev E. 2019 Dec;100(6-1):062417. doi: 10.1103/PhysRevE.100.062417.
The properties of cardiac muscle are anisotropic, and the degree of anisotropy may be different in the intracellular and extracellular spaces. In the electrical bidomain model, such "unequal anisotropy ratios" of the conductivity lead to unanticipated behavior. In the mechanical bidomain model, unequal anisotropy ratios of the mechanical moduli might also result in unanticipated behavior. In this study, mathematical modeling based on the mechanical bidomain model is used to calculate the distribution of mechanotransduction in cardiac tissue when it is stretched. This analysis demonstrates that unexpected phenomena arise when the mechanical anisotropy ratios are unequal.
心肌的性质具有各向异性，且各向异性程度在细胞内和细胞外空间可能不同。在电双域模型中，这种电导率的“各向异性比不等”会导致意想不到的行为。在机械双域模型中，机械模量的各向异性比不等也可能导致意想不到的行为。在这项研究中，使用基于机械双域模型的数学建模来计算心脏组织在拉伸时机械转导的分布。该分析表明，当机械各向异性比不等时会出现意想不到的现象。
