Sepulveda N G, Roth B J, Wikswo J P
Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235.
Biophys J. 1989 May;55(5):987-99. doi: 10.1016/S0006-3495(89)82897-8.
A two-dimensional sheet of anisotropic cardiac tissue is represented with the bidomain model, and the finite element method is used to solve the bidomain equations. When the anisotropy ratios of the intracellular and extracellular spaces are not equal, the injection of current into the tissue induces a transmembrane potential that has a complicated spatial dependence, including adjacent regions of depolarized and hyperpolarized tissue. This behavior may have important implications for the electrical stimulation of cardiac tissue and for defibrillation.
二维各向异性心脏组织薄片由双域模型表示，采用有限元方法求解双域方程。当细胞内和细胞外空间的各向异性比率不相等时，向组织中注入电流会诱发一种跨膜电位，该电位具有复杂的空间依赖性，包括去极化和超极化组织的相邻区域。这种行为可能对心脏组织的电刺激和除颤具有重要意义。
