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Inhibitors of sterol synthesis. 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol induces changes in the sterol composition and the morphology of CHO-K1 cells.

作者信息

Pinkerton F D, Izumi A, Schroepfer G J

机构信息

Department of Biochemistry, Rice University, Houston, Texas 77251.

出版信息

Biochem Biophys Res Commun. 1988 Nov 30;157(1):359-63. doi: 10.1016/s0006-291x(88)80055-x.

DOI:10.1016/s0006-291x(88)80055-x
PMID:3196343
Abstract

Incubation of CHO-K1 cells in lipid-deficient medium containing 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol (0.1 microM) for 4 days was associated with a profound change in cellular sterol composition as reflected by a marked accumulation of lanosterol and 24,25-dihydrolanosterol. A striking elongation of the cells was also observed. Incubation of CHO-K1 cells in lipid-deficient medium containing lanosterol (10 microM) also caused a significant accumulation of lanosterol which was also associated with a marked elongation of the cells.

摘要

相似文献

1
Inhibitors of sterol synthesis. 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol induces changes in the sterol composition and the morphology of CHO-K1 cells.
Biochem Biophys Res Commun. 1988 Nov 30;157(1):359-63. doi: 10.1016/s0006-291x(88)80055-x.
2
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引用本文的文献

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Lipids. 1996 May;31(5):453-87. doi: 10.1007/BF02522641.