Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, 605 Fenglin Avenue, Nanchang 330013, China.
Molecules. 2020 Jan 17;25(2):388. doi: 10.3390/molecules25020388.
Hf(OTf) was identified as a highly potent catalyst (0.1-0.5 mol%) for three-component Mannich reaction under solvent-free conditions. Hf(OTf)-catalyzed Mannich reaction exhibited excellent regioselectivity and diastereoselectivity when alkyl ketones were employed as substrates. H NMR tracing of the H/D exchange reaction of ketones in MeOH- indicated that Hf(OTf) could significantly promote the keto-enol tautomerization, thereby contributing to the acceleration of reaction rate.
六氟合铪（OTf）被鉴定为无溶剂条件下三组分曼尼希反应的高效催化剂（0.1-0.5mol%）。当使用烷基酮作为底物时，Hf（OTf）催化的曼尼希反应表现出优异的区域选择性和立体选择性。在 MeOH-中酮的 H/D 交换反应的 NMR 跟踪表明，Hf（OTf）可以显著促进酮-烯醇互变异构，从而有助于反应速率的加速。
