Lu Zengkui, Yue Yaojing, Yuan Chao, Liu Jianbin, Chen Zhiqiang, Niu Chune, Sun Xiaoping, Zhu Shaohua, Zhao Hongchang, Guo Tingting, Yang Bohui
Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
Sheep Breeding Engineering Technology Research Center of Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
Animals (Basel). 2020 Jan 19;10(1):170. doi: 10.3390/ani10010170.
Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. The results showed that 113 single nucleotide polymorphisms (SNPs) reached the genome-wide significance levels for the four body weight traits and 30 genes were annotated effectively, including , , , and . The genes annotated by these SNPs significantly enriched 78 gene ontology terms and 25 signaling pathways, and were found to mainly participate in skeletal muscle development and lipid metabolism. These genes can be used as candidate genes for body weight in sheep, and provide useful information for the production and genomic selection of Chinese fine-wool sheep.
体重是绵羊的一项重要经济性状，对其生产繁殖的成功至关重要。因此，确定有助于理解体重性状变异性的基因组区域和生物学途径对于选择目的具有重要意义。在本研究中，利用重测序技术确定了460只细毛羊出生、断奶、周岁和成年体重的全基因组关联。结果表明，113个单核苷酸多态性（SNP）达到了这四个体重性状的全基因组显著水平，有效注释了30个基因，包括 、 、 、 。这些SNP注释的基因显著富集了78个基因本体术语和25条信号通路，并且发现主要参与骨骼肌发育和脂质代谢。这些基因可作为绵羊体重的候选基因，为中国细毛羊的生产和基因组选择提供有用信息。
