WNT 信号通路与疾病
WNT Signaling in Disease.
机构信息
Division of Science, Yale-NUS College, Yale-NUS College Research Labs @ E6, E6, 5 Engineering Drive 1, #04-02, Singapore 117608, Singapore.
出版信息
Cells. 2019 Aug 3;8(8):826. doi: 10.3390/cells8080826.
Abstract
Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans. Here, we discuss the WNT pathway and its role in human disease and some of the advances in WNT-related treatments.
摘要
发育信号通路在胚胎发生和成年期控制着大量的生物学过程。WNT 途径在癌症和发育中同时被发现。最近的进展扩大了 WNT 在人类多种疾病中的作用。在这里，我们讨论了 WNT 途径及其在人类疾病中的作用，以及与 WNT 相关的治疗方法的一些进展。
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