Department of Clinical Laboratory Medicine, Nanyang Central Hospital, Nanyang, China.
Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China.
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029619900552. doi: 10.1177/1076029619900552.
von Willebrand factor (VWF) acts as a bridge between platelets and the subendothelial matrix following vessel damage and plays a vital role in coronary artery disease (CAD). The aim of this study was to investigate the association between VWF and the severity of coronary stenosis quantified by the Gensini score in acute myocardial infarction (AMI), the most dangerous complication of CAD. Plasma VWF antigen (VWF: Ag) and VWF-collagen binding (VWF: CB) in normal controls (n = 123) and in patients with AMI (n = 205) were tested, and then the patients were divided based on Gensini scores. The levels of VWF: Ag and VWF: CB in patients with AMI were significantly higher than those in the control group ( < .001). Plasma levels of VWF: Ag and VWF: CB were positively correlated with both Gensini score and the number of affected vessels. Both VWF: Ag and VWF: CB were independent factors for coronary stenosis, adjusting confounding factors. Thus, the levels of VWF: Ag and VWF: CB were positively correlated with the severity of coronary stenosis. Screening of VWF at time of AMI may have prognostic value in terms of the severity of coronary stenosis.
血管性血友病因子（VWF）在血管损伤后作为血小板与内皮下基质之间的桥梁，在冠状动脉疾病（CAD）中起着至关重要的作用。本研究旨在探讨血管性血友病因子（VWF）与急性心肌梗死（AMI）中冠状动脉狭窄严重程度的关系，AMI 是 CAD 最危险的并发症。检测了正常对照组（n = 123）和 AMI 患者（n = 205）的血浆 VWF 抗原（VWF：Ag）和 VWF-胶原结合（VWF：CB），然后根据 Gensini 评分对患者进行分组。AMI 患者的 VWF：Ag 和 VWF：CB 水平明显高于对照组（ <.001）。VWF：Ag 和 VWF：CB 的血浆水平与 Gensini 评分和受累血管数量呈正相关。VWF：Ag 和 VWF：CB 均为冠状动脉狭窄的独立因素，可调整混杂因素。因此，VWF：Ag 和 VWF：CB 的水平与冠状动脉狭窄的严重程度呈正相关。在 AMI 时筛查 VWF 可能对冠状动脉狭窄的严重程度具有预后价值。
