Exercise Epidemiology, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark; Centre of Research in Childhood Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Exercise Epidemiology, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark; Centre of Research in Childhood Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Environ Int. 2020 Mar;136:105481. doi: 10.1016/j.envint.2020.105481. Epub 2020 Jan 18.
Lipophilic compounds such as polychlorinated biphenyls (PCBs) are primarily stored in adipose tissue, but exercise-induced lipolysis is able to release PCBs from the adipose tissue into the circulation. The plasma concentration, distribution and metabolism of PCBs can thus vary much among individuals due to inter-human variations in lifestyle behavior and pharmacokinetics.
We examined the observational relationship of circulating plasma PCB concentrations with cardiorespiratory fitness, engagement in vigorous physical activity and fat mass in a healthy Danish child population.
Data on ∑PCB (PCB138, PCB153 and PCB180), cardiorespiratory fitness, skinfold thickness and objectively measured physical activity of 509 children derived from the Danish sub-study of The European Youth Heart Study.
Higher fitness and greater leanness were associated with elevated plasma ∑PCB in both boys and girls. The associations were independent of each other and persisted after controlling for socio-economic status and duration of breastfeeding. We observed an almost three-fold increase in plasma ∑PCB level in the most fit/least fat children relative to the least fit/most fat children. The association between fatness and ∑PCB was strongest for boys as girls, and especially pubertal girls, displayed lower decrease in plasma ∑PCB with higher fat mass.
Our findings suggest that increased lipolysis stimulates the release of PCBs into the vasculature. The consequence is higher plasma levels of PCB in very fit and lean subjects. This scenario is likely to cause negative confounding in epidemiological observations of PCB and cardio-metabolic health. At the same time adipose tissue may play a dual role in promoting adverse health and providing a relatively safe place to store PCB.
脂溶性化合物，如多氯联苯（PCBs），主要储存在脂肪组织中，但运动引起的脂肪分解能够将 PCBs 从脂肪组织释放到循环中。因此，由于个体间生活方式行为和药代动力学的差异，PCBs 在血浆中的浓度、分布和代谢有很大的不同。
我们在一个健康的丹麦儿童人群中，研究了循环血浆 PCB 浓度与心肺功能适应性、剧烈体力活动参与度和体脂量之间的观察性关系。
来自欧洲青年心脏研究丹麦子研究的数据包括 509 名儿童的∑PCB（PCB138、PCB153 和 PCB180）、心肺功能适应性、皮褶厚度和客观测量的体力活动。
在男孩和女孩中，更高的适应性和更瘦的体型与更高的血浆∑PCB 水平相关。这些关联彼此独立，并且在控制了社会经济地位和母乳喂养时间后仍然存在。我们观察到，在最适应/最瘦的儿童与最不适应/最胖的儿童相比，血浆∑PCB 水平几乎增加了三倍。脂肪量与∑PCB 的关联在男孩中最强，而女孩，尤其是青春期女孩，随着体脂量的增加，血浆∑PCB 的下降幅度较低。
我们的发现表明，脂肪分解的增加刺激了 PCBs 向血管的释放。其结果是，在非常适应和瘦的受试者中，血浆 PCB 水平更高。这种情况可能会对 PCB 与心血管代谢健康的流行病学观察产生负面影响。同时，脂肪组织可能在促进不良健康和提供相对安全的 PCB 储存场所方面发挥双重作用。
