Centre de Recherche du Centre Hospitalier Universitaire de Québec, Québec, Canada.
Centre de Recherche du Centre Hospitalier Universitaire de Québec, Québec, Canada; Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S1085, F-35000, Rennes, France.
Environ Res. 2020 Oct;189:109924. doi: 10.1016/j.envres.2020.109924. Epub 2020 Jul 11.
BACKGROUND/AIMS: Given that their traditional lifestyle and diet still relies on fish and other marine species for sustenance, the Inuit are highly exposed to polychlorinated biphenyls (PCBs) and PCBs are increasingly linked to obesity. However, evidence is not consistent regarding which periods of exposure are most relevant. In this study, we examine whether in utero, childhood, and adolescent exposure to PCBs are related to physical growth at adolescence.
Inuit adolescents from Canada (N=212) enrolled in a prospective longitudinal cohort study since birth were assessed for height, weight, body mass index (BMI), fat mass index (FMI) and fat free mass index (FFMI) at 18 years of age. PCB 153 concentrations were quantified in blood samples obtained at birth (umbilical cord), 11, and 18 years of age. Maternal anthropometrics were measured and those for the newborns collected from medical records. Data on biological mothers and participants' sociodemographic characteristics and food security were collected using interviews. Multiple linear regression analyses were used to test associations between PCB 153 concentrations and adolescent anthropometric measures.
Cord PCB 153 was not related to height or FFMI at adolescence. By contrast, analyses showed that cord PCB 153 was related to higher BMI, FMI and marginally to weight in girls but not boys. Child PCB 153 was not related to height, weight or FFMI in adolescence. Child PCB 153 was related to lower BMI and FMI at adolescence in both sexes, particularly among those considered overweight or obese during childhood. Adolescent PCB 153 was not associated with any outcome.
This study suggests that prenatal exposure to PCBs may have a long-term effect on growth in early adulthood among girls and identifies the peri-pubertal period as another window of sensitivity for the action of PCBs. Our findings also suggest that exposure to PCBs and body size be documented in multiple time periods from infancy to adulthood.
背景/目的：由于因纽特人的传统生活方式和饮食仍然依赖鱼类和其他海洋物种来维持生计，他们高度暴露于多氯联苯（PCBs）中，而 PCBs 与肥胖的关联性日益增强。然而，关于哪些暴露期最为相关的证据并不一致。在这项研究中，我们研究了胎儿期、儿童期和青少年期接触 PCBs 是否与青春期的身体生长有关。
自出生以来，加拿大的因纽特青少年（N=212）参加了一项前瞻性纵向队列研究，在 18 岁时评估他们的身高、体重、体重指数（BMI）、脂肪质量指数（FMI）和无脂肪质量指数（FFMI）。在出生（脐带）、11 岁和 18 岁时采集血液样本，定量分析 PCB153 浓度。测量母婴的人体测量学指标，并从医疗记录中收集新生儿的相关指标。通过访谈收集关于生物母亲和参与者社会人口特征以及粮食安全的数据。使用多元线性回归分析来测试 PCB153 浓度与青少年人体测量指标之间的关联。
脐带 PCB153 与青春期身高或 FFMI 无关。相比之下，分析表明脐带 PCB153 与女孩的 BMI、FMI 较高有关，与男孩的 BMI 相关但无统计学意义。儿童期 PCB153 与青春期身高、体重或 FFMI 无关。儿童期 PCB153 与两性的青春期 BMI 和 FMI 较低有关，特别是在儿童期超重或肥胖的人群中。青少年期 PCB153 与任何结果均无关。
本研究表明，产前接触 PCBs 可能对女孩成年早期的生长有长期影响，并确定青春期是 PCBs 作用的另一个敏感期。我们的研究结果还表明，应在从婴儿期到成年期的多个时间点记录 PCBs 暴露和身体大小。
