PTEN 在胰岛素信号转导和抵抗中的代谢作用。
Metabolic Role of PTEN in Insulin Signaling and Resistance.
机构信息
Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.
Institute of Medical Science, University of Toronto, Toronto, Ontario M5G 2M9, Canada.
出版信息
Cold Spring Harb Perspect Med. 2020 Aug 3;10(8):a036137. doi: 10.1101/cshperspect.a036137.
Abstract
Phosphatase and tensin homolog (PTEN) is most prominently known for its function in tumorigenesis. However, a metabolic role of PTEN is emerging as a result of its altered expression in type 2 diabetes (T2D), which results in impaired insulin signaling and promotion of insulin resistance during the pathogenesis of T2D. PTEN functions in regulating insulin signaling across different organs have been identified. Through the use of a variety of models, such as tissue-specific knockout (KO) mice and in vitro cell cultures, PTEN's role in regulating insulin action has been elucidated across many cell types. Herein, we will review the recent advancements in the understanding of PTEN's metabolic functions in each of the tissues and cell types that contribute to regulating systemic insulin sensitivity and discuss how PTEN may represent a promising therapeutic strategy for treatment or prevention of T2D.
摘要
磷酸酶和张力蛋白同源物（PTEN）最突出的功能是在肿瘤发生中发挥作用。然而，由于其在 2 型糖尿病（T2D）中的表达改变，PTEN 的代谢作用正在显现，这导致在 T2D 的发病机制中胰岛素信号受损和胰岛素抵抗的促进。已经确定了 PTEN 在调节不同器官中胰岛素信号的功能。通过使用各种模型，如组织特异性敲除（KO）小鼠和体外细胞培养，已经阐明了 PTEN 在调节许多细胞类型中的胰岛素作用中的作用。在此，我们将回顾理解 PTEN 在有助于调节全身胰岛素敏感性的每种组织和细胞类型中的代谢功能的最新进展，并讨论 PTEN 如何可能成为治疗或预防 T2D 的有前途的治疗策略。
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