Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia
Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Pract Neurol. 2020 May;20(3):234-240. doi: 10.1136/practneurol-2019-002335. Epub 2020 Jan 21.
Ageing, genetic, medical and lifestyle factors contribute to the risk of Alzheimer's disease and other dementias. Around a third of dementia cases are attributable to modifiable risk factors such as physical inactivity, smoking and hypertension. With the rising prevalence and lack of neuroprotective drugs, there is renewed focus on dementia prevention strategies across the lifespan. Neurologists encounter many people with risk factors for dementia and are frequently asked whether lifestyle changes may help. Exercise has emerged as a key intervention for influencing cognition positively, including reducing the risk of age-related cognitive decline and dementia. This article focuses on the current evidence for physical inactivity as a modifiable dementia risk factor and aims to support neurologists when discussing risk reduction.
年龄、遗传、医疗和生活方式因素都会增加患阿尔茨海默病和其他类型痴呆症的风险。大约三分之一的痴呆病例可归因于可改变的风险因素，如身体活动不足、吸烟和高血压。由于痴呆症的发病率不断上升，且缺乏神经保护药物，因此人们重新关注终生的痴呆症预防策略。神经科医生会遇到许多存在痴呆症风险因素的患者，并且经常被问到生活方式的改变是否有帮助。锻炼已成为影响认知的关键干预措施，包括降低与年龄相关的认知能力下降和痴呆症的风险。本文重点介绍身体活动不足作为可改变的痴呆风险因素的现有证据，并旨在为神经科医生讨论降低风险提供支持。
