University of Trieste, Piazzale Europa 2, 34100, Trieste, Italy.
Institute for Maternal and Child Health-IRCCS, "Burlo Garofolo"-Via dell'Istria 65/1, 34100, Trieste, Italy.
Eur J Pediatr. 2020 Jun;179(6):993-997. doi: 10.1007/s00431-020-03574-y. Epub 2020 Jan 21.
The objective of the study is to evaluate the efficacy of corticosteroids in Sydenham chorea. This is a retrospective observational study. Clinical information of children with Sydenham chorea were collected. Outcome of Sydenham chorea was evaluated in consideration of presence or absence of corticosteroid therapy. Thirty patients were enrolled. A total of 15 were treated with prednisone, 15 received symptomatic drugs or no treatment. Patients who were treated with prednisone showed faster improvement (4 vs 16 days; p = 0.002) and shorter median time of remission (30 vs 135 days; p < 0.001).Conclusion: Our study showed that corticosteroid therapy is an effective treatment of Sydenham chorea.What is Known:• Steroid treatment in Sydenham chorea is widely used but it is not standardized.• Few manuscript report a beneficial use of steroids in Sydenham chorea if compared with no treatment.What is New:• Steroid treatment seems to be effective in both clinical remission and clinical improvement of symptoms among patients with Sydenham chorea.• Steroid treatment seems to be superior to conventional treatment.
这项研究的目的是评估皮质类固醇治疗风湿性舞蹈病的疗效。这是一项回顾性观察研究。收集了患有风湿性舞蹈病的儿童的临床信息。考虑皮质类固醇治疗的存在与否，评估风湿性舞蹈病的转归。共纳入 30 例患者。其中，15 例接受泼尼松治疗，15 例接受对症药物治疗或未治疗。接受泼尼松治疗的患者恢复更快（4 天 vs 16 天；p=0.002），缓解中位时间更短（30 天 vs 135 天；p<0.001）。结论：本研究表明，皮质类固醇治疗是风湿性舞蹈病的有效治疗方法。已知情况：• 风湿性舞蹈病中使用类固醇治疗已广泛应用，但尚未标准化。• 与未治疗相比，少数文献报道皮质类固醇在风湿性舞蹈病中的有益作用。新发现：• 皮质类固醇治疗似乎对风湿性舞蹈病患者的症状临床缓解和临床改善均有效。• 皮质类固醇治疗似乎优于常规治疗。
