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急性风湿热:拉丁美洲一个中等收入国家的15年单中心经验

Acute rheumatic fever: 15-year single-center experience of a middle-income country in Latin America.

作者信息

Lozano-Espinosa Diego A, Márquez-Herrera Kelly C, Huertas-Quiñonez Víctor M, Sanguino-Lobo Roy, Díaz-Maldonado Adriana

机构信息

Pediatric Cardiology Unit, HOMI, Fundación Hospital Pediátrico La Misericordia.

Pediatric Infectology Unit, Clínica Infantil Santa María del Lago.

出版信息

Arch Cardiol Mex. 2025;95(2):199-206. doi: 10.24875/ACM.24000155.

DOI:10.24875/ACM.24000155
PMID:40445950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12058087/
Abstract

OBJECTIVE

Acute rheumatic fever (ARF) is the leading cause of acquired heart disease in children and young adults in developing countries. The objective is to describe the clinical and epidemiological presentation of patients under 18 years of age with ARF in a pediatric hospital in Colombia over a period of 15 years (2006-2020), emphasizing cardiac involvement.

METHODS

Case series study of children with rheumatic fever for 15 years (2006 to 2020).

RESULTS

Seventy patients under the age of 18 with criteria for acute rheumatic fever were evaluated. Mean age was 10 years. Chorea was the most frequent manifestation (n = 51, 72.8%) followed by carditis (n = 31, 44.2%). Cases of ARF were proportionally more frequent from 2015 (43/70, 61.4%), as did the frequency of carditis (19/31, 61.2%) and subclinical carditis (7/11, 63.6%). Eight percent had a PR prolongation.

CONCLUSIONS

The incidence in this study is high (moderate-risk). Chorea was the most frequent initial manifestation, which reflects the late diagnosis. The case frequency of acute rheumatic fever, especially for carditis and subclinical carditis, increased considerably beginning in 2015. Echocardiographic is trascendent because 35.4% of cases with carditis were subclinical.

摘要

目的

在发展中国家,急性风湿热(ARF)是儿童和青年获得性心脏病的主要病因。目的是描述哥伦比亚一家儿科医院15年(2006 - 2020年)期间18岁以下ARF患者的临床和流行病学表现,重点关注心脏受累情况。

方法

对15年(2006年至2020年)期间患风湿热的儿童进行病例系列研究。

结果

对70例符合急性风湿热标准的18岁以下患者进行了评估。平均年龄为10岁。舞蹈病是最常见的表现(n = 51,72.8%),其次是心脏炎(n = 31,44.2%)。2015年起ARF病例比例更高(43/70,61.4%),心脏炎(19/31,61.2%)和亚临床心脏炎(7/11,63.6%)的发生率也是如此。8%的患者PR间期延长。

结论

本研究中的发病率较高(中度风险)。舞蹈病是最常见的初始表现,这反映了诊断延迟。急性风湿热的病例数,尤其是心脏炎和亚临床心脏炎的病例数,从2015年开始大幅增加。超声心动图检查至关重要,因为35.4%的心脏炎病例为亚临床病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ff/12058087/c95d3a1d2229/10971AMEX252-ACM-95-199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ff/12058087/c95d3a1d2229/10971AMEX252-ACM-95-199-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ff/12058087/c95d3a1d2229/10971AMEX252-ACM-95-199-g001.jpg

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