Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, New York.
J Orthop Res. 2020 Jul;38(7):1423-1435. doi: 10.1002/jor.24595. Epub 2020 Jan 31.
Prosthetic joint infection (PJI) is a devastating complication that results in substantial costs to society and patient morbidity. Advancements in our knowledge of this condition have focused on prevention, diagnosis, and treatment, in order to reduce rates of PJI and improve patient outcomes. Preventive measures such as optimization of patient comorbidities, and perioperative antibiotic usage are intensive areas of current clinical research to reduce the rate of PJI. Improved diagnostic tests such as synovial fluid (SF) α-defensin enzyme-linked immunosorbent assay, and nucleic acid-based tests for serum, SF, and tissue cultures, have improved diagnostic accuracy and organism identification. Increasing the diversity of available antibiotic therapy, immunotherapy, and alternative implant coatings remain promising treatments to improve infection eradication in the setting of PJI.
人工关节感染（PJI）是一种破坏性的并发症，会给社会和患者带来巨大的经济负担和发病率。为了降低 PJI 的发生率并改善患者的预后，我们在预防、诊断和治疗方面取得了进展。预防措施，如优化患者的合并症和围手术期抗生素的使用，是当前临床研究的重点领域，以降低 PJI 的发生率。改进的诊断试验，如滑液（SF）α-防御素酶联免疫吸附试验和基于核酸的血清、SF 和组织培养物的检测方法，提高了诊断准确性和病原体鉴定。增加可用抗生素治疗、免疫治疗和替代植入物涂层的多样性仍然是改善 PJI 感染清除的有前途的治疗方法。
